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Pharmacological targeting transient receptor potential canonical channel 6 modulates biological behaviors for cervical cancer HeLa and SiHA cell
BackgroundThis study aimed to observe the effect of transient receptor potential canonical channel 6 (TRPC6) antagonist 1-(β-[3-(4-method-phenyl)...
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In Vitro Study of Cytostatic Activity of Baicalin, Baicalein, and Chlorophyllipt on HeLa-v Cell Line
Cytostatic activity of baicalin, baicalein, and neogalenical drug Chlorophyllipt was studied in vitro on HeLa-v cells. Standard samples of Eucalimin,...
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Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons
The unique properties of superparamagnetic iron oxide nanoparticles (SPIONs) enable their use as magnetic biosensors, targeted drug delivery,...
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Lappaconitine sulfate inhibits proliferation and induces mitochondrial-mediated apoptosis via regulating PI3K/AKT/GSK3β signaling pathway in HeLa cells
Lappaconitine (LA), a diterpenoid alkaloid extracted from the root of Aconitum sinomontanum Nakai, exhibits broad pharmacological effects, including...
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Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway
Several in vitro studies along with some in vivo studies have shown the anti-cancer activity of bromelain against several types of cancer except...
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Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents
Although micronuclei are well-known biomarkers of genotoxic damage, the biological consequences of micronucleus induction are only poorly understood....
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Culture of Continuous Cell Lines
This chapter describes the culture of various continuous cell lines. Continuous cell lines are generated either due to specific genetic or epigenetic...
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Genotoxicity of pyrrolizidine alkaloids in metabolically inactive human cervical cancer HeLa cells co-cultured with human hepatoma HepG2 cells
Pyrrolizidine alkaloids (PAs) are secondary plant metabolites, which can be found as contaminant in various foods and herbal products. Several PAs...
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Novel vitamin K3 analogs containing 3-N-substituted aromatic and piperazine rings with selective in vitro anticancer activity against HeLa, U87 MG, and MCF-7 cells
In this study, firstly, novel vitamin K3 analogs were synthesized by the reactions of vitamin K3 (2-methyl-1,4-naphthoquinone, also known as...
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Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo
Betulinic acid (BA), a naturally occurring lupane-type triterpenoid, possesses a wide range of potential activities against different types of...
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Inulin Stearate Self-assembly Micro-rod Containing Paclitaxel: Synthesis and In Vitro Cytotoxicity MTT Assay in HeLa Cell Line
IntroductionCervical cancer is one of the most common cancers among women, and its mortality rate is increasing rapidly. Drugs such as paclitaxel are...
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A Highly Selective Fluorescent Probe for Imaging Hydrogen Sulfide in Living HeLa Cells
As an important endogenous gasotransmitter, hydrogen sulfide (H 2 S) has been implicated with a variety of biological processes and has attracted more...
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Fluid shear stress influences invasiveness of HeLa cells through the induction of autophagy
Extravasation of metastatic cells from the blood or lymphatic circulation and formation of secondary tumor at a distant site is a key step of cancer...
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Activating transcription factor 3 mediates apoptotic functions through a p53-independent pathway in human papillomavirus 18 infected HeLa cells
Activating transcription factor 3 (ATF3) is the first p53 stability regulator that interferes with the ubiquitination of p53. However, the E6...
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Effect of Co-Treatment with Static Magnetic Fieldand Cis-diamminedichloroplatinum(II) on Apoptosis and Cell Cycle Progression in HeLa Cell Line and Hu02
AbstractIn this research, we evaluated the combined effect of static magnetic field and cis -diamminedichloroplatinum(II) (CDDP) on cell death,...
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Microbial Contamination of Mammalian Cell Culture
Contamination is commonly used as a term for the presence of undesired microorganisms, unwanted mammalian cells, and various biochemical or chemicals...
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Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells
Elevated expression of the nucleoporin Nup88, a constituent of the nuclear pore complex, is seen in various types of malignant tumors, but whether...
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Cancer Cell Lines: Its Implication for Therapeutic Use
The purpose of this mini-review, which is developed for the education of general public, is to make readers acquainted with the usefulness of cancer...
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Development of a New Drug Delivery System from HELA-Derived Exosomes and the Effect of Docetaxel-Loaded Exosomes on Mitochondrial Apoptosis
PurposeExosomes have the potential to create new therapeutics as drug loading carriers. Their important inherent roles are stem from structures (also...
