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Evaluation of immunophenotypic alterations of peripheral blood lymphocytes and their sub-sets in uncomplicated P. Falciparum infection
BackgroundMalaria is a life-threatening parasitic disease typically transmitted through the bite of an infected Anopheles mosquito. There is ample...
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A Population Pharmacokinetic Model of Whole-Blood and Intracellular Tacrolimus in Kidney Transplant Recipients
Background and ObjectiveThe tacrolimus concentration within peripheral blood mononuclear cells may correlate better with clinical outcomes after...
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In vitro delayed response to dihydroartemisinin of malaria parasites infecting sickle cell erythocytes
BackgroundDecreased efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria has been previously reported in...
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Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells
BackgroundDysregulation of microRNA-based mechanisms is associated with various human pathologies, including gestational diabetes mellitus (GDM),...
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Dried Blood Spots—A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM)
This review provides an overview on the current applications of dried blood spots (DBS) as matrices for therapeutic drug (TDM) and drug or disease...
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Screening of malaria infections in human blood samples with varying parasite densities and anaemic conditions using AI-Powered mid-infrared spectroscopy
BackgroundEffective testing for malaria, including the detection of infections at very low densities, is vital for the successful elimination of the...
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Effects of Short-Term Exercise on Iron Status and Haematological Parameters of Apparently Healthy Males in Ado Ekiti, Ekiti State, Nigeria
BackgroundIron is needed for many biological processes but can be extremely harmful when intake is excessive. Exercise brings about iron deficiency...
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Reliability and feasibility of home-based dried blood spot in therapeutic drug monitoring: a systematic review and meta-analysis
PurposeDried blood spot (DBS) is one of promising home sampling methods for therapeutic drug monitoring (TDM). However, the associated reliability...
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Improving malaria preventive practices and pregnancy outcomes through a health education intervention: A randomized controlled trial
BackgroundThe prevalence of malaria in pregnancy and its complications, remain very high in Nigeria. This study aimed to determine the effects of a...
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Lecture 21: Pressure and Fluid Dynamics
Pressure is the force (in N) being exerted, divided by the area (in m2) on which the force acts. Note that pressure is NOT a force (nor is it a...
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Pre-acclimation to altitude in young adults: choosing a hypoxic pattern at sea level which provokes significant haematological adaptations
PurposeThis single-blind, repeated measures study evaluated adaptive and maladaptive responses to continuous and intermittent hypoxic patterns in...
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Age-related declines in muscle and respiratory function are proportionate to declines in performance in Master Track Cyclists
PurposeRespiratory and musculoskeletal function decline with age, irrespective of physical activity levels. Previous work has suggested that the...
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Blood count changes in malaria patients according to blood groups (ABO/Rh) and sickle cell trait
IntroductionIntroduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub- Saharan Africa. In...
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Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury
Administration of bolus intravenous fluids, common in pre-hospital and hospitalised patients, is associated with increased lung vascular permeability...
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Generation of Plasmodium falciparum Gametocytes In Vitro with Specific Considerations for Field Isolates
Reproducible induction of gametocytes of Plasmodium falciparum in vitro is crucial for performing various experimental analyses to understand...
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Safety and feasibility of apheresis to harvest and concentrate parasites from subjects with induced blood stage Plasmodium vivax infection
BackgroundIn the absence of a method to culture Plasmodium vivax , the only way to source parasites is ex vivo. This hampers many aspects of P. vivax ...
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Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes
The rapid elimination of nanoparticles from the bloodstream by the mononuclear phagocyte system limits the activity of many nanoparticle...
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Experimental study of newly described avian malaria parasite Plasmodium (Novyella) collidatum n. sp., genetic lineage pFANTAIL01 obtained from South Asian migrant bird
BackgroundAvian malaria parasites are microorganisms parasitizing erythrocytes and various tissues of the birds; they are common and distributed...
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Plasmodium falciparum neonatal malaria with atypical presentation: a case series from southwestern Ethiopia
BackgroundNeonatal malaria is defined as the detection of asexual stages of Plasmodium species in the cord blood within the first 28 days of life....