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Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models
BackgroundEvaluation of parasite clearance patterns in experimental human infection trials helps increase understanding of drug action. In a...
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Cell-Free DNA, MicroRNAs, Proteins, and Peptides as Liquid Biopsy Biomarkers in Prostate Cancer and Bladder Cancer
Liquid biopsy, as a novel noninvasive tool for biomarker discovery, has gained a lot of attention and represents a significant innovation in...
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PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility
BackgroundNeuroendocrine prostate cancer (NEPC) is a lethal subset of prostate cancer which is characterized by neuroendocrine differentiation and...
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Research progress on non-protein-targeted drugs for cancer therapy
Non-protein target drugs, especially RNA-based gene therapies for treating hereditary diseases, have been recognized worldwide. As cancer is an...
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Hormone Therapy for Advanced Prostate Cancer
The identification of probable sources of androgen and strategies for lowering their levels are essential to the characterization of advanced PC. The...
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Epigenetic mechanisms underlying prostate cancer radioresistance
Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly prevalent neoplasm among males worldwide. About 30% of newly...
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Stem cell transplantation as a progressing treatment for retinitis pigmentosa
Retinal degenerative diseases such as retinitis pigmentosa (RP) are of the major causes of vision loss in developed countries. Despite the unclear...
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Palliative radiotherapy to dominant symptomatic lesion in patients with hormone refractory prostate cancer (PRADO)
BackgroundThis study was conducted to investigate a new short-course radiotherapy regimen for patients with metastatic hormone refractory prostate...
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Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers
Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to...
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The pyridazine heterocycle in molecular recognition and drug discovery
The pyridazine ring is endowed with unique physicochemical properties, characterized by weak basicity, a high dipole moment that subtends π-π...
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Dendritic Cell-Based Cancer Immunotherapy
Dendritic cells (DCs) are the immune system headquarter with outstanding capabilities in initiating, linking, and directing immune responses with...
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Impact of preoperative prostate magnetic resonance imaging on the surgical management of high-risk prostate cancer
ObjectiveTo evaluate the effect of adding multiparametric magnetic resonance imaging (mpMRI) to pre-surgical planning on surgical decision making for...
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Compendium of Mechanistic Insights of Distinct Conventional Anticancer Therapies and Their Grievous Toxicities
Omitting cardiovascular diseases, cancer is the first chief death cause globally (Nagai and Kim 2017; Siegel et al. 2020). The term cancer includes...
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Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties
Acquired docetaxel-resistance of prostate cancer (PCa) remains a clinical obstacle due to the lack of effective therapies. Acetyl-11-keto-β-boswellic...
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Origins of Suicide Gene Therapy
“Tumor chemosensitivity” can be achieved by the expression of the herpes simplex virus thymidine kinase gene in cells, followed by the conversion of...
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Cancer Immunotherapy
Cancer is the second leading cause of death in the United States, accounting for approximately 23% of deaths from all causes. Cancer results from a...
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Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision
Photoreceptors (PRs), as the most abundant and light-sensing cells of the neuroretina, are responsible for converting light into electrical signals...
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Combining Histone Deacetylase Inhibitors with Other Anticancer Agents as a Novel Strategy for Circumventing Limited Therapeutic Efficacy and Mitigating Toxicity
Although histone deacetylase inhibitors (HDACi) are emerging as prosperous therapeutics for cancer therapy yet they exert only modest cytotoxic...