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HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC
BackgroundImmune checkpoint blockade (ICB) only works well for a certain subset of patients with non-small cell lung cancer (NSCLC). Therefore,...
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Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer
PurposeReliable biomarkers to predict the outcome and treatment response of estrogen receptor (ER)-negative breast cancer (BC) are urgently needed....
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A promising Prognostic risk model for advanced renal cell carcinoma (RCC) with immune-related genes
BackgroundRenal cell carcinoma (RCC) is a third most common tumor of the urinary system. Nowadays, Immunotherapy is a hot topic in the treatment of...
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Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
BackgroundAcute respiratory distress syndrome (ARDS) is characterized by non-cardiogenic pulmonary edema caused by inflammation, which can lead to...
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The gene expression profile and cell of origin of canine peripheral T-cell lymphoma
BackgroundPeripheral T-cell lymphoma (PTCL) refers to a heterogenous group of T-cell neoplasms with poor treatment responses and survival times....
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Integration of RNA-Seq and proteomics data identifies glioblastoma multiforme surfaceome signature
BackgroundGlioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a prevalence of approximately 2 per 10,000 people globally....
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RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation
BackgroundEffective treatment is needed for advanced, inoperable, or chemotherapy-resistant cervical cancer patients. Immunotherapy has become a new...
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Expression profile analysis identifies key genes as prognostic markers for metastasis of osteosarcoma
BackgroundOS is the most common malignant tumor of bone which was featured with osteoid or immature bone produced by the malignant cells, and...
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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Convergent lines of evidence support BIN1 as a risk gene of Alzheimer’s disease
Genome-wide association studies (GWAS) have identified several susceptibility loci of Alzheimer’s disease (AD), which were mainly located in...
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Gene Expression in Synovium of Rotator Cuff Tear Patients Determined by RNA Sequencing
Rotator cuff tear (RCT) is a common shoulder disorder related to pain and dysfunction. However, the pathological mechanism of RCT remains unclear....
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Dog leukocyte antigen genoty** across class I and class II genes in beagle dogs as laboratory animals
Dog leukocyte antigen (DLA) polymorphisms have been found to be associated with inter-individual variations in the risk, susceptibility, and severity...
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HLA Genetics for the Human Diseases
Highly polymorphic human leukocyte antigen (HLA) molecules (alleles) expressed by different classical HLA class I and class II genes have crucial...
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How to Predict Binding Specificity and Ligands for New MHC-II Alleles with MixMHC2pred
MHC-II molecules are key mediators of antigen presentation in vertebrate species and bind to their ligands with high specificity. The very high...
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Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations
AbstractThe risk of severe COVID-19 increases with age as older patients are at highest risk. Thus, there is an urgent need to identify how severe...
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BAP1 mutations inhibit the NF-κB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma
BackgroundTumor immune microenvironment regulates the growth and metastasis of uveal melanoma (UM). This study aims to reveal the possible molecular...
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The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
BackgroundThe Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct...
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Overexpression of SH2D1A promotes cancer progression and is associated with immune cell infiltration in hepatocellular carcinoma via bioinformatics and in vitro study
BackgroundSH2 domain containing 1A ( SH2D1A) expression has been linked to cancer progression. However, the functions of SH2D1A in hepatocellular...
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Single-cell RNA sequencing reveals a peripheral landscape of immune cells in Schistosomiasis japonica
BackgroundSchistosomiasis, also known as bilharzia, is a devastating parasitic disease. This progressive and debilitating helminth disease is often...
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A healthy live birth after mosaic blastocyst transfer in preimplantation genetic testing for GATA1-related cytopenia combined with HLA matching
BackgroundGATA1-related cytopenia (GRC) is characterized by thrombocytopaenia and/or anaemia ranging from mild to severe. Haematopoietic stem cell...
