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HLA in Population Genetics
Historically, the genetic markers of immunoglobulin allotypes (IG) located in the constant domains of IgG antibodies have been used to trace...
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HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A...
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The impact of HLA polymorphism on herpesvirus infection and disease
Human Leukocyte Antigens (HLA) are cell surface molecules, central in coordinating innate and adaptive immune responses, that are targets of strong...
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HLA Genes and Molecules
In this chapter I describe the genomic organization of the MHC in humans, namely, the HLA system and the molecular structure of HLA class-I and...
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Association of HLA-DRB1*11 and HLA-DRB1*12 gene polymorphism with COVID-19 in Burkina Faso
BackgroundThe clinical manifestations of coronavirus disease (COVID-19) can vary widely, ranging from asymptomatic to severe, and may be influenced...
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HLA and Disease Association
An interesting application of HLA in medicine was the description of the increased incidence of some HLA class-I and class-II alleles in patients...
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HLA Genetics for the Human Diseases
Highly polymorphic human leukocyte antigen (HLA) molecules (alleles) expressed by different classical HLA class I and class II genes have crucial...
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The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides
The physiological expression of HLA-G is mainly observed in the placenta, playing an essential role in maternal–fetal tolerance. Among the HLA-G mRNA...
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Association of HLA-G 3′UTR polymorphisms with hepatitis B virus infection in Tunisian population
Hepatitis B virus (HBV) infection is a major public health burden. The mechanisms of immune evasion during chronic HBV (CHB) infection are poorly...
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The association of HLA-G polymorphism with oral and genital HPV infection in men
The host genetic factors that influence the natural history of human papillomavirus (HPV) infection in men are not well known. Our aim was to...
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Imputation-Based HLA Ty** with GWAS SNPs
SNP-based imputation approaches for human leukocyte antigen (HLA) ty** take advantage of the haplotype structure within the major...
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Deep Learning-Based HLA Allele Imputation Applicable to GWAS
Human leukocyte antigen (HLA) imputation is an essential step following genome-wide association study, particularly when putative associations in HLA...
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Investigation of the Relationship between Polymorphism of Human Leukocyte Antigen G (HLA-G) and Social Functioning of Patients with Schizophrenia
AbstractDisorders of social functioning are the most persistent consequences of schizophrenia and are an important factor influencing the prognosis...
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Submitting Novel Full-Length HLA, MIC, and KIR Alleles with TypeLoader2
The Immuno Polymorphism Database (IPD) plays a pivotal role for immunogenetics. Due to technical limitations, genoty** often focuses on specific...
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Contribution of HLA class I (A, B, C) and HLA class II (DRB1, DQA1, DQB1) alleles and haplotypes in exploring ethnic origin of central Tunisians
BackgroundEstimation of HLA (Human leukocyte Antigen) alleles’ frequencies in populations is essential to explore their ethnic origin. Anthropologic...
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Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles
In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a...
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Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population
BackgroundThe human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical...
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Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and acquired immunity. Their functions include antigen...
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MHC/HLA Class-I Loss and Cancer Immune Escape
This chapter is about the progress made in the clinical application of tumour immunology. It describes the discovery of tumour antigens recognized by...
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Comprehensive HLA Ty** from a Current Allele Database Using Next-Generation Sequencing Data
HLA allele information is essential for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune...