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HIF-1α- and HIF-2α-Immunopositive Neurons and Capillaries in the Prefrontal Cerebral Cortex of Rats with Experimental Myocardial Infarction
The quantitative content of HIF-1α- and HIF-2α-immunopositive brain neurons in Wistar rats was studied 1, 15, and 30 days after modeling of...
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Role of HIF-1 in Brain Tumor Development
HIFs are the transcription factors which respond to the low oxygen concentration in the cellular environment of hypoxia (Smith et al. 2008; Wilkins...
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Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy
Hypoxia-inducible Factor 1 (HIF-1) is a transcriptional activator that intervenes in versatile reactions to hypoxia. Natural drugs, widely...
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Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β
BackgroundThe main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are...
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Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
ObjectiveHypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors are a new class of anti-anemia agents. We retrospectively evaluated the...
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Exploring the role of tRNA-derived small RNAs (tsRNAs) in disease: implications for HIF-1 pathway modulation
The tRNA-derived small RNAs (tsRNAs) can be categorized into two main groups: tRNA-derived fragments (tRFs) and tRNA-derived stress-induced RNAs...
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HIF-1α Pathway Orchestration by LCN2: A Key Player in Hypoxia-Mediated Colitis Exacerbation
In this study, we investigated the role of hypoxia in the development of chronic inflammatory bowel disease (IBD), focusing on its impact on the...
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Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1α activation
BackgroundCancer is characterized by dysregulated cellular metabolism. Thus, understanding the mechanisms underlying these metabolic alterations is...
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HIF-1 signaling: an emerging mechanism for mitochondrial dynamics
A growing emphasis has been paid to the function of mitochondria in tumors, neurodegenerative disorders (NDs), and cardiovascular diseases....
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Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner
BackgroundCancer cells in severely hypoxic regions have been reported to invade towards tumour blood vessels after surviving radiotherapy in a...
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PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease
BackgroundMedial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life...
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Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation
BackgroundThe terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metabolic disturbances...
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Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
The hypoxia-inducible factor-1α (HIF-1α) pathway coordinates skeletal bone homeostasis and endocrine functions. Activation of the HIF-1α pathway...
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HIF-1α Induced by Hypoxia Promotes Peripheral Nerve Injury Recovery Through Regulating Ferroptosis in DRG Neuron
Peripheral nerve injury (PNI) usually has a poor effect on functional recovery and severely declines the patient’s quality of life. Our prior...
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Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1α mediated activation
Microglia cells are activated in response to different stress signals. Several metabolic adaptations underlie microglia activation in the brain....
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PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer
BackgroundAberrant epigenetic remodeling events contribute to progression and metastasis of breast cancer (Bca). The specific mechanims that...
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The role of hypoxia-inducible factor 1 alpha (HIF-1α) modulation in heavy metal toxicity
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-sensing transcriptional regulator orchestrating a complex of adaptive cellular responses to hypoxia....
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AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth
BackgroundCancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress...
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The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation,...
