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HERV-K (HML-2) insertion polymorphisms in the 8q24.13 region and their potential etiological associations with acute myeloid leukemia
Human endogenous retroviruses (HERVs) are LTR retrotransposons that are present in the human genome. Among them, members of the HERV-K (HML-2) group...
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Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
BackgroundHuman endogenous retroviruses (HERVs) result from ancestral infections caused by exogenous retroviruses that became incorporated into the...
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HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA
BackgroundThe HERV-K (HML-2) viruses are the youngest of the human endogenous retroviruses. They are present as several almost complete proviral...
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HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome
BackgroundChronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life...
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Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22
BackgroundThe human genome contains remnants of ancient retroviral infections called human endogenous retroviruses (HERV). Their expression is often...
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HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis
Human endogenous retroviruses (HERVs) are the remnants of ancient retroviral infections integrated into the human genome. Although most HERVs are...
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Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
BackgroundThe cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage of endogenous retroviruses is a potentially attractive...
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Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity and disease subgroups. The...
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Evaluating the expression level of HERV-K env, np9, rec and gag in breast tissue
ObjectiveBreast cancer is one of the most common health problems. It has been suggested that several risk factors, either considered as external or...
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The Molecular Link Between TDP-43, Endogenous Retroviruses and Inflammatory Neurodegeneration in Amyotrophic Lateral Sclerosis: a Potential Target for Triumeq, an Antiretroviral Therapy
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a progressive neurological disorder, characterised by the death of...
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Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology
BackgroundCritically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely to...
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Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?
The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact...
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Correction to: Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
An amendment to this paper has been published and can be accessed via the original article.
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Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis
Over the past two decades a number of studies have demonstrated activity of the retroviral enzyme reverse transcriptase in the serum of patients with...
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Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the...
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Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis
The study of the role of retroviruses in amyotrophic lateral sclerosis (ALS) dates back to the 1960s shortly after transposable elements themselves...
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Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing
BackgroundHuman endogenous retroviruses (HERVs), suspected to be transposition-defective, may reshape the transcriptional network of the human genome...
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Human endogenous retroviruses env gene expression and long terminal repeat methylation in colorectal cancer patients
Human endogenous retroviruses (HERV) are remnants of exogenous retroviral infections, representing 8% of the human genome. Their regulation is based...
