Search
Search Results
-
Molecular epidemiology and genetic evolution of avian influenza H5N1 subtype in Nigeria, 2006 to 2021
Nigeria recorded one of the earliest outbreaks of the Highly Pathogenic Avian Influenza (HPAI) virus H5N1 in 2006, which spread to other African...
-
A computational approach to design a multiepitope vaccine against H5N1 virus
Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized as a possible pandemic hazard to men and the...
-
Phylogeography and gene pool analysis of highly pathogenic avian influenza H5N1 viruses reported in India from 2006 to 2021
India has reported highly pathogenic avian influenza (HPAI) H5N1 virus outbreaks since 2006, with the first human case reported in 2021. These...
-
A new clade 2.3.4.4b H5N1 highly pathogenic avian influenza genotype detected in Europe in 2021
Despite their widespread distribution, only a single genotype variant of clade 2.3.4.4b H5N1 influenza viruses has been found so far in Europe. Here,...
-
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
-
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss our current understanding...
-
Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3
BackgroundInfluenza A virus (IAV) can cause severe and life-threatening illness in humans and animals. Therefore, it is important to search for host...
-
Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt
The first detection of a human infection with avian influenza A/H6N1 virus in Taiwan in 2013 has raised concerns about this virus. During our routine...
-
Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic...
-
Influenza Virus Entry inhibitors
Influenza is a major challenge to health and the global economy. However, the increasing emergence of drug resistance during influenza pandemics...
-
Influenza A Virus Neuraminidase Inhibitors
Depending on the strain, influenza A virus causes animal, zoonotic, pandemic, or seasonal influenza with varying degrees of severity. Two surface...
-
Attenuation of A(H7N9) influenza virus infection in mice exposed to cigarette smoke
Influenza A(H7N9) virus showed high pathogenicity in humans when it emerged in 2013. Cigarette smoke (CS) causes pulmonary diseases including...
-
Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm
The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle,...
-
Influenza from a One Health Perspective: Infection by a Highly Versatile Virus
Influenza A viruses (IAVs) are among the most versatile viruses, in terms of host range, pathogenesis, route of transmission, transmissibility...
-
A mosaic influenza virus-like particles vaccine provides broad humoral and cellular immune responses against influenza A viruses
The development of a universal influenza vaccine to elicit broad immune responses is essential in reducing disease burden and pandemic impact. In...
-
H6N2 reassortant avian influenza virus isolate in wild birds in Jiangxi Province, China
H6 avian influenza virus is widely prevalent in wild birds and poultry and has caused human infection in 2013 in Taiwan, China. During our active...
-
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain...
-
The biological characteristics and infection dynamics of a novel H3N2 canine influenza virus genotype in beagles
BackgroundThe canine influenza virus (CIV) outbreak has garnered considerable attention as it poses a significant threat to dog health. During the...
-
Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
Current Influenza virus vaccines primarily induce antibody responses against variable epitopes in hemagglutinin (HA), necessitating frequent updates....
-
The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir
Genetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza...
