Search
Search Results
-
A multiplex real-time RT-PCR assay for the detection of H1, H2 and H3 subtype avian influenza viruses
Avian influenza viruses (AIVs) are influenza A viruses, of which subtypes H1, H2 and H3 are highly transmissible in poultry and have the risk of...
-
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial
Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and there remains a need for novel vaccine platforms capable...
-
A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination
Conserved epitopes on the influenza hemagglutinin (HA) stem are an attractive target for universal vaccine strategies as they elicit broadly...
-
Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain
The relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated...
-
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide...
-
Antigen-capture ELISA and immunochromatographic test strip to detect the H9N2 subtype avian influenza virus rapidly based on monoclonal antibodies
BackgroundThe H9N2 subtype of avian influenza virus (AIV) has become the most widespread subtype of AIV among birds in Asia, which threatens the...
-
H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2 −/− ...
-
A novel epitope-blocking ELISA for specific and sensitive detection of antibodies against H5-subtype influenza virus hemagglutinin
BackgroundH5-subtype highly pathogenic (HP) avian influenza viruses (AIVs) cause high mortality in domestic birds and sporadic infections in humans...
-
Discovery of oxazolidinone-based heterocycles as subtype selective sigma-2 ligands
The sigma-2 (σ 2 ) receptor, also known as the Transmembrane Protein 97 (TMEM97, and MAC30 (Meningioma-associated protein), has been linked to a number...
-
Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China
BackgroundAvian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype...
-
Role of stromal PD-L1 expression in colorectal liver metastasis
Background and AimThe outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of...
-
Microscopic and molecular prevalence and associated risk factors with Toxocara and Blastocystis infection in dogs and cats in Mitidja, Algeria
Domestic dogs and cats can serve as a source of environmental contamination with Toxocara spp. and Blastocystis spp., and this represents a neglected...
-
Estimation of Avian Influenza Viruses in Water Environments of Live Poultry Markets in Changsha, China, 2014 to 2018
In routine surveillance for avian influenza viruses (AIVs) in the environments of live poultry markets (LPMs), certain samples were positive for AIVs...
-
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
BackgroundAmongst risk alleles associated with late-onset Alzheimer’s disease (AD), those that converged on the regulation of microglia activity have...
-
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Intracerebral hemorrhage is a common neurological disease, and its pathological mechanism is complex. As the first recruited leukocyte subtype after...
-
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain...
-
Novel Loss of Function (G15D) Mutation on RAC2 in a Family with Combined Immunodeficiency and Increased Levels of Immunoglobulin G, A, and E
Ras-related C3 botulinum toxin substrate 2 (RAC2) is a small guanine nucleotide binding molecule that is exclusively expressed in hematopoietic cell...
-
New Haplotypes of Blastocystis sp. Identified in Faeces from Various Animal Groups in Algeria
PurposeBlastocystis sp. is a single-celled, anaerobic, parasitic protozoan commonly found in the intestinal tract of animals and humans globally....
-
The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy
BackgroundViral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their...
