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Efficacy and safety of guttiferone E in melanoma-bearing mice
Melanoma, an aggressive and potentially fatal skin cancer, is constrained by immunosuppression, resistance, and high toxicity in its treatment....
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Oblongifolin C and guttiferone K extracted from Garcinia yunnanensis fruit synergistically induce apoptosis in human colorectal cancer cells in vitro
Oblongifolin C (OC) and guttiferone K (GUTK) are two anticancer compounds extracted from Garcinia yunnanensis Hu, but they act by different...
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Effect of the metanolic extract from the leaves of Garcinia humilis Vahl (Clusiaceae) on acute inflammation
Garcinia humilis is popularly used to treat digestive, intestinal and inflammatory illness. We investigated the in vivo and in vitro effects of the...
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The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation
BackgroundIn a cytotoxicity screen in serum-free medium, Guttiferone F showed strong growth inhibitory effect against prostate cancer cells.
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A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervis and their biological activities
A new biflavonoid, paucinervin K ( 1 ) and a new triterpene, 23-hydroxy-friedelin ( 2 ), together with eleven known compounds 3 - 13 were isolated from the...
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Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study
Recent publications have suggested that African medicinal plants and their derived products could be viable source of new and better trypanocidal...
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Dietary restriction: could it be considered as speed bump on tumor progression road?
Dietary restrictions, including fasting (or long-term starvation), calorie restriction (CR), and short-term starvation (STS), are considered a strong...
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Natural products as modulator of autophagy with potential clinical prospects
Natural compounds derived from living organisms are well defined for their remarkable biological and pharmacological properties likely to be...
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Garcinol and Its Role in Chronic Diseases
The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to...
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SIRT1 and Neural Cell Fate Determination
During the development of the central nervous system (CNS), neurons and glia are derived from multipotent neural stem cells (NSCs) undergoing...
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Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice
This study was undertaken to evaluate the gastroprotective properties of seed, leaf, and branch methanolic extracts and guttiferone A obtained from Gar...
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The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids
Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery...
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HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents
Histone deacetylase (HDAC) inhibitors represent a new class of anticancer agents that target dysregulated acetylation of histone lysines, an...
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Analgesic and anti-inflammatory effect of aqueous extract of the stem bark of Allanblackia gabonensis (Guttiferae)
Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the...
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Antifungal Activity of Medicinal Plant Extracts and Phytocompounds: A Review
The epidemiological data suggest that the incidence and prevalence of serious mycoses continues to be a public health problem. The increased use of...
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Volume 6 Indexes
This index lists all 3367 normalized pharmacological activity terms appeared in the encyclopedia in alphabetical order and a number code sequence of...