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Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases
Parkinson’s disease is a chronic neuropathy characterised by the formation of Lewy bodies (misfolded alpha-synuclein) in dopaminergic neurons of the...
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Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Activation of Gasdermin D (GSDMD) results in its cleavage, oligomerization, and subsequent formation of plasma membrane pores, leading to a form of...
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Gut Microbiome and Brain Aging
The concept that the gut microbiota plays a significant role in maintaining physiological status in the gastrointestinal (GI) system is supported by...
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Influence of Altered Gut Microbiota in Cellular Senescence
Senescence is a physiological process a cell undergoes. This process is often considered as a double-edged sword as it as both beneficial and...
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Role of Gut Brain and Gut Oral Axis in Progression of Parkinson’s Disease with Special Focus on Gut Microbes
The function of the microbiome in human health and disease has become one of the most important issues in modern medicine. Currently, a growing...
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Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
Ischemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity,...
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Applied physiology: gut microbiota and antimicrobial therapy
The gut microbiota plays an important role in maintaining human health and in the pathogenesis of several diseases. Antibiotics are among the most...
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Co-localization of antibiotic resistance genes is widespread in the infant gut microbiome and associates with an immature gut microbial composition
BackgroundIn environmental bacteria, the selective advantage of antibiotic resistance genes (ARGs) can be increased through co-localization with...
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H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers
BackgroundHydrogen gas (H 2 ) is a common product of carbohydrate fermentation in the human gut microbiome and its accumulation can modulate...
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Targeting gut microbiota for immunotherapy of diseases
With advances in next-generation sequencing technology, there is growing evidence that the gut microbiome plays a key role in the host’s innate and...
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From Gut Microbiomes to Infectious Pathogens: Neurological Disease Game Changers
Gut microbiota and infectious diseases affect neurological disorders, brain development, and function. Compounds generated in the gastrointestinal...
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Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective
Tissue-resident memory T cells (T RM ) serve as the frontline of host defense, playing a critical role in protection against invading pathogens. This...
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Gut microbiome and cardiometabolic comorbidities in people living with HIV
BackgroundDespite modern antiretroviral therapy (ART), people living with HIV (PLWH) have increased relative risk of inflammatory-driven...
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Exploring the Interplay Between Gut Microflora and Parkinson’s
One of the crucial elements in sustaining host health and disease is the gut microbiota. The gut microbiota is now recognized as one of the critical...
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Gut microenvironmental changes as a potential trigger in Parkinson’s disease through the gut–brain axis
Parkinson’s disease (PD) is the second most common neurodegenerative disease attributed to the synergistic effects of genetic risk and environmental...
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Microglia in Microbiota-Gut-Brain Axis: A Hub in Epilepsy
There is growing concern about the role of the microbiota-gut-brain axis in neurological illnesses, and it makes sense to consider microglia as a...
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The Gut Microbiota and NDG: What Is the Interplay
The GIT has various cell types in proximate regions and is exposed to the gut microbiota and dietary components on its luminal side of the external...
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Metabolic network of the gut microbiota in inflammatory bowel disease
Gut dysbiosis is closely linked to the pathogenesis of inflammatory bowel disease (IBD). Emerging studies highlight the relationship between host...
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Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis...
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Gut commensal Enterocloster species host inoviruses that are secreted in vitro and in vivo
BackgroundBacteriophages in the family Inoviridae , or inoviruses, are under-characterized phages previously implicated in bacterial pathogenesis by...
