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Cardiac optogenetics: shining light on signaling pathways
In the early 2000s, the field of neuroscience experienced a groundbreaking transformation with the advent of optogenetics. This innovative technique...
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Direct investigation of cell contraction signal networks by light-based perturbation methods
Cell contraction plays an important role in many physiological and pathophysiological processes. This includes functions in skeletal, heart, and...
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Photodynamic and Light-Response Nanomaterials Against Multidrug-Resistant Bacteria
Antimicrobial resistance (AMR) is a life-threatening concern worldwide. To combat this issue, ongoing research is focused on advanced nanoparticle... -
Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy
The marine flavobacterium Krokinobactereikastus light-driven sodium pump (KR2) generates an outward sodium ion current under 530 nm light...
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The Role of Colour Segmented Fluorescence (CSF) Mode and Same-day Administration of Low-dose Indocyanine Green in Liver Surgery: Our Initial Experience
Indocyanine green (ICG) fluorescence image guidance (I-FIGS) is increasingly used in liver surgery. Several regimens have been described regarding...
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Multiphoton Phosphorescence of Simple Ketones by Visible-light Excitation and Its Consideration for Active Sensing in Space
Acetone and butanone were seen to emit blue light around 450 nm when excited in the green by a high intensity pulsed laser. The pathway of this...
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Effects of illuminance intensity on the green channel of remote photoplethysmography (rPPG) signals
Point-of-care remote photoplethysmography (rPPG) devices that utilize low-cost RGB cameras have drawn considerable attention due to their convenience...
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Solvent effect on the Spectra of Methylene Green and Methylene Blue
This investigation focuses on dyes that differ only in the nitro substituent. The NO 2 group leads to a strong hardening of the fluorescence at 298 K....
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Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice
There is a demand for noninvasive methods to ameliorate disease. We investigated whether 40-Hz flickering light entrains gamma oscillations and...
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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
Channelrhodopsins are used widely for optical control of neurons, in which they generate photoinduced proton, sodium or chloride influx. Potassium (K + ...
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Light-responsive biomaterials for ocular drug delivery
Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic acids, where the tunable/precise delivery of payload...
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Volumetric Imaging of Neural Activity by Light Field Microscopy
Recording the highly diverse and dynamic activities in large populations of neurons in behaving animals is crucial for a better understanding of how...
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Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES
Optogenetic actuators are rapidly advancing tools used to control physiology in excitable cells, such as neurons and cardiomyocytes. In neuroscience,...
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High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue
Histological examinations typically require the excision of tissue, followed by its fixation, slicing, staining, mounting and imaging, with...
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Mast cell stabilization: new mechanism underlying the therapeutic effect of intense pulsed light on rosacea
BackgroundRosacea, a chronic inflammatory disorder of the facial skin, is effectively treated by intense pulsed light (IPL).
Objective ... -
Light-Based Neuronal Circuit Probing in Living Brains at High Resolution: Constraints and Layouts for Integrating Neuronal Activity Recording and Modulation in Three Dimensions
Understanding how the brain orchestrates neuronal activity to finely produce and regulate behavior is an intriguing yet challenging task. In the last... -
Opsins outside the eye and the skin: a more complex scenario than originally thought for a classical light sensor
Since the discovery of melanopsin as a retinal non-visual photopigment, opsins have been described in several organs and cells. This distribution is...
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Towards Transabdominal Functional Photoacoustic Imaging of the Placenta: Improvement in Imaging Depth Through Optimization of Light Delivery
Functional photoacoustic imaging of the placenta could provide an innovative tool to diagnose preeclampsia, monitor fetal growth restriction, and...
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Tetherless Optical Neuromodulation: Wavelength from Orange-red to Mid-infrared
Optogenetics, a technique that employs light for neuromodulation, has revolutionized the study of neural mechanisms and the treatment of neurological...
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References for Small Fluorescence Quantum Yields
Three compounds with fluorescence quantum yields in the range of 10 − 5 to 10 − 4 and emission spectra covering the UV/Vis spectral range are suggested...