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Unrealized targets in the discovery of antibiotics for Gram-negative bacterial infections
Advances in areas that include genomics, systems biology, protein structure determination and artificial intelligence provide new opportunities for...
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Beta-Lactam Resistance in Gram-Negative Bacteria Threats and Challenges
This timely book discusses antimicrobial drug resistance, specifically, the resistance against the beta-lactam class of antibiotics by Gram-Negative...
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Potent synergy and sustained bactericidal activity of polymyxins combined with Gram-positive only class of antibiotics versus four Gram-negative bacteria
BackgroundGram-negative bacteria (GNB) are becoming increasingly resistant to a wide variety of antibiotics. There are currently limited treatments...
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Diagnostic strategy of metagenomic next-generation sequencing for gram negative bacteria in respiratory infections
ObjectiveThis study aims to identify the most effective diagnostic method for distinguishing pathogenic and non-pathogenic Gram-negative bacteria...
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In vitro antibacterial activities of essential oils and extracts of six herbals against gram-positive and gram-negative bacteria
ObjectConsidering the development of bacterial resistance to chemical antibiotics and their adverse effects on the environment and public health,...
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Carriage of multidrug-resistant Gram-negative bacilli: duration and risk factors
Identification of risk factors influencing the duration of carriage of multidrug-resistant Gram-negative bacilli (MDR-GNB) may be useful for...
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The cholesteryl-ester transfer protein isoform (CETPI) and derived peptides: new targets in the study of Gram-negative sepsis
BackgroundSepsis is a syndrome where the dysregulated host response to infection threatens the life of the patient. The isoform of the...
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Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice
Chronic stress causes maladaptive changes in the brain that lead to depressive behavior. In the present study, we investigate whether chronic stress...
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The use of new antibacterial drugs against infections caused by multidrug-resistant Gram-negative bacteria: an Italian real-world evidence study in a Lombardy hospital
Infections caused by multidrug-resistant (MDR) bacteria are typically associated with high morbidity and mortality, especially in vulnerable...
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Persistent bacteremia predicts poor outcomes among neutropenic patients with carbapenem-resistant gram-negative bloodstream infections receiving appropriate therapy
PurposeIdentifying persistent bacteremia early in patients with neutropenia may improve outcome. This study evaluated the role of follow-up blood...
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The IMD and Toll canonical immune pathways of Triatoma pallidipennis are preferentially activated by Gram-negative and Gram-positive bacteria, respectively, but cross-activation also occurs
BackgroundAntimicrobial peptides (AMPs) participate in the humoral immune response of insects eliminating invasive microorganisms. The immune...
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Multidrug-resistant Gram-negative bacterial infections and associated factors in a Kenyan intensive care unit: a cross-sectional study
BackgroundPatients admitted to intensive care units (ICU) are at risk of Gram-negative bacteria (GNB) infections, especially those caused by...
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Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications
Alzheimer’s disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline....
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Incidence of catheter-associated urinary tract infections by Gram-negative bacilli and their ESBL and carbapenemase production in specialized hospitals of Bahir Dar, northwest Ethiopia
BackgroundCatheter-associated urinary tract infections (CAUTIs) due to multidrug-resistant Gram-negative bacilli (GNB) is a common concern globally....
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Activity of ceftolozane/tazobactam and imipenem/relebactam against clinical gram-negative isolates from Czech Republic, Hungary, and Poland—SMART 2017–2020
Antimicrobial susceptibility was determined for clinical gram-negative isolates from Czech Republic, Hungary, and Poland, where published data for...
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TIVAP-related infection due to Gram-negative aerobic bacilli: should TIVAP stay or should it go?
We aimed to describe the outcome of totally implantable venous-access port (TIVAP)-related infections due to Gram-negative aerobic bacilli ( Pseudomona...
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Intraventricular or intrathecal polymyxin B for treatment of post-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria: a 8-year retrospective study
PurposePost-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria (CRGNB) is a life-threatening complication....
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Structure activity relationship (SAR) driven design and discovery of WCK 5107 (Zidebactam): novel β-lactam enhancer, potent against multidrug-resistant gram-negative pathogens
Extended-spectrum beta-lactamases (ESBL) are the enzymes responsible for producing multidrug-resistant (MDR) bacterial strains, making currently...
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An Overview on Antibiotic Resistance in Gram-Negative Bacteria
Antimicrobial agents have been in use since ages in various forms in curing bacterial infections. Gram-negative bacteria cause a wide range of...
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A decade of neonatal sepsis in Stockholm, Sweden: Gram-positive pathogens were four times as common as Gram-negatives
PurposeTo assess Gram-positive bacterial (GPB) bloodstream infection (BSI) in neonates, covering incidence, morbidity, mortality, antimicrobial...
