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STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
Objective and designKidney stones commonly occur with a 50% recurrence rate within 5 years, and can elevate the risk of chronic kidney disease....
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The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans
PurposeChronic β-alanine supplementation leads to increased levels of muscle histidine-containing dipeptides. However, the majority of ingested...
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Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis
BackgroundAccumulated studies reported abnormal gene expression profiles of hepatocellular carcinoma (HCC) by cDNA microarray. We tried to merge cDNA...
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The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae
BackgroundCarbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens...
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LncRNA CRNDE promotes hepatoma cell proliferation by regulating the metabolic reprogramming of M2 macrophages via ERK pathway
BackgroundLncRNA colorectal neoplasia differentially expressed (CRNDE) was found to be an important regulator in many cancers. This project focuses...
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Parallel Metabolomic Profiling of Cerebrospinal Fluid, Plasma, and Spinal Cord to Identify Biomarkers for Spinal Cord Injury
Loss of physical and emotional health due to spinal cord injury (SCI) has been rapidly increasing worldwide. Effective evaluation of the severity of...
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Molecular analysis of the AGXT gene in Syrian patients suspected with primary hyperoxaluria type 1
BackgroundCharacterization of the molecular basis of primary hyperoxaluria type 1 (PH-1) in Syria has been accomplished through the analysis of 90...
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Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata
BackgroundEmergence of Candida glabrata , which causes potential life-threatening invasive candidiasis, has been widely associated with high...
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Metagenomic characterization of a novel non-ammonia-oxidizing Thaumarchaeota from hadal sediment
BackgroundThe hadal sediment, found at an ocean depth of more than 6000 m, is geographically isolated and under extremely high hydrostatic pressure,...
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Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice
BackgroundGiven the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on...
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Metabolomics Provides Novel Insights into Epilepsy Diagnosis and Treatment: A Review
Epilepsy is one of the most common diseases of the central nervous system. The diagnosis of epilepsy mainly depends on electroencephalograms and...
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Urinary microbiome dysbiosis is associated with an inflammatory environment and perturbed fatty acids metabolism in the pathogenesis of bladder cancer
BackgroundBladder cancer is a common malignancy with high recurrence rate. Early diagnosis and recurrence surveillance are pivotal to patients’...
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Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study
RationaleThe mechanisms underlying major depressive disorder (MDD) in children and adolescents are unclear. Metabolomics has been utilized to capture...
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High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer
BackgroundGastric cancer (GC) is one of the most common and fatal cancers worldwide. Effective biomarkers to aid the early diagnosis of GC, as well...
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Glycolate as a Biological Marker of B Vitamins
Recent research results have revealed that the nutritional status of B vitamins and glycolate (glycolic acid, GA) metabolism are closely related. GA...
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Glycolate as a Biological Marker of B Vitamins
Recent research results have revealed that the nutritional status of B vitamins and glycolate (glycolic acid, GA) metabolism are closely related. GA...
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Progress with RNA Interference for the Treatment of Primary Hyperoxaluria
Over the last few years, US Food and Drug Administration-approved drugs using RNA interference have come to the market. Many have treated...
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