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Glycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway
BackgroundRenal cell carcinoma (RCC) is a hypermetabolic disease. Abnormal up-regulation of glycolytic signaling promotes tumor growth, and...
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Metformin suppresses proliferation and glycolysis of gastric cancer by modulating ADAMTS12
BackgroundGastric cancer (GC) is a common malignancy with its morbidity increasing worldwide. Hence, it is imperative to develop effective...
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Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression
BackgroundThe Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs...
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MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1
MARCH5 is a ring-finger E3 ubiquitin ligase located in the outer membrane of mitochondria. A previous study has reported that MARCH5 was up-regulated...
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m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells,...
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A hypoxia–glycolysis–lactate-related gene signature for prognosis prediction in hepatocellular carcinoma
BackgroundLiver cancer ranks sixth in incidence and third in mortality globally and hepatocellular carcinoma (HCC) accounts for 90% of it. Hypoxia,...
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Hypoxia promotes metastasis by relieving miR-598-3p-restricted glycolysis in gastric cancer
The activation of glycolysis, particularly in the context of reprogrammed energy metabolism, is increasingly recognized as a significant...
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CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis
BackgroundChaperonin Containing TCP1 Subunit 6 A (CCT6A) is a prominent protein involved in the folding and stabilization of newly synthesized...
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Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers
BackgroundNeoadjuvant chemotherapy (NAC) is the standard of care for patients with early-stage triple negative breast cancers (TNBC). However, more...
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Long noncoding RNAs: glycolysis regulators in gynaecologic cancers
The three most common gynaecologic cancers that seriously threaten female lives and health are ovarian cancer, cervical cancer, and endometrial...
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Aerobic Glycolysis in Photoreceptors Supports Energy Demand in the Absence of Mitochondrial Coupling
Metabolism is adapted to meet energetic needs. Based on the amount of ATP required to maintain plasma membrane potential, photoreceptor energy...
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Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
BackgroundAcute myeloid leukemia (AML) is a hematopoietic malignancy. Chidamide has shown anti-cancer effect in different malignancies. The function...
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The emerging role of glycolysis and immune evasion in gastric cancer
Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Similar to other types of...
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Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis
Inflammatory bowel diseases (IBDs) are prevalent and debilitating diseases with limited clinical treatment strategies. Mesenchymal stem cell (MSCs)...
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Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
It is generally thought that under basal conditions, neurons produce ATP mainly through mitochondrial oxidative phosphorylation (OXPHOS), and...
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NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
BackgroundBioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide...
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Natural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic...
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The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells
BackgroundNeuroblastoma (NB), the most common extracranial solid malignancy in children, carries a poor prognosis in high-risk disease, thus...
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Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma
BackgroundMetabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC)....
