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Therapeutic implications of glucose transporters (GLUT) in cerebral ischemia
Cerebral ischemia is a leading cause of death in the globe, with a large societal cost. Deprivation of blood flow, together with consequent glucose...
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Functional importance of glucose transporters and chromatin epigenetic factors in Glioblastoma Multiforme (GBM): possible therapeutics
Glioblastoma Multiforme (GBM) is an aggressive brain cancer affecting glial cells and is chemo- and radio-resistant. Glucose is considered the most...
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Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers
BackgroundBrain capillary endothelial cells (BCECs) experience hypoxic conditions during early brain development. The newly formed capillaries are...
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The glucose transporter GLUT12, a new actor in obesity and cancer
Obesity constitutes a global health epidemic which worsens the main leading death causes such as type 2 diabetes, cardiovascular diseases, and...
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A Comprehensive Review of Membrane Transporters and MicroRNA Regulation in Alzheimer’s Disease
Alzheimer’s disease (AD) is a distressing neurodegenerative condition characterized by the accumulation of amyloid-beta (Aβ) plaques and tau tangles...
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Regulation of Glucose Transporters in Cancer Progression
Glycolysis has been one of the major hallmarks of cancer, as cancer cells exhibit a high rate of glucose consumption beyond that required for energy...
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The expression and survival significance of sodium glucose transporters in pancreatic cancer
BackgroundSodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However,...
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
Mast cells (MCs) are known to have a pathological impact in a variety of settings, in particular in allergic conditions. There is also limited...
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Glucose transporters in pancreatic islets
The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters with distinct transport characteristics. In the pancreatic...
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Opisthorchis viverrini excretory-secretory products suppress GLUT8 of cholangiocytes
Opisthorchis viverrini infection and the subsequent bile duct cancer it induces remains a significant public health problem in Southeast Asia....
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Glucose transporters in brain in health and disease
Energy demand of neurons in brain that is covered by glucose supply from the blood is ensured by glucose transporters in capillaries and brain cells....
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Metabolic Transporters in the Peripheral Nerve—What, Where, and Why?
Cellular metabolism is critical not only for cell survival, but also for cell fate, function, and intercellular communication. There are several...
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The role of exercise and hypoxia on glucose transport and regulation
Muscle glucose transport activity increases with an acute bout of exercise, a process that is accomplished by the translocation of glucose...
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Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress
Glutamate, one of the most important excitatory neurotransmitters, acts as a signal transducer in peripheral tissues and endocrine cells. Excessive...
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Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus
Melatonin receptor 1B (MT2, encoded by the MTNR1B gene), a high-affinity receptor for melatonin, is associated with glucose homeostasis including...
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Glucose transporters in cardiovascular system in health and disease
Glucose transporters are essential for the heart to sustain its function. Due to its nature as a high energy-consuming organ, the heart needs to...
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Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
BackgroundBlood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been...
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Structure, function and regulation of mammalian glucose transporters of the SLC2 family
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal...
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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
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Exercise-Regulated Skeletal Muscle Glucose Uptake
Muscle glucose uptake during exercise is regulated by a coordinated increase in glucose delivery (via increased blood flow and glucose moving out of...