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Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Recent therapeutic advances have significantly uplifted the quality of life in breast cancer patients, yet several impediments block the road to...
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Stress-induced Neuroinflammation of the Spinal Cord is Restrained by Cort113176 (Dazucorilant), A Specific Glucocorticoid Receptor Modulator
Glucocorticoids exert antiinflammatory, antiproliferative and immunosupressive effects. Paradoxically they may also enhance inflammation particularly...
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Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the glucocorticoid receptor (GR) have been linked to major depressive...
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Role of glucocorticoid receptor mutations in hypertension and adrenal gland hyperplasia
Hypertension is one of the leading causes of premature death in humans and exhibits a complex aetiology including environmental and genetic factors....
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Quantification of transcriptome changes to investigate the role of glucocorticoid receptor-RNA binding during dexamethasone treatment
ObjectivesThe glucocorticoid receptor (GR) is a well-studied, ligand-activated transcription factor and a common target of anti-inflammatory...
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Effects of Glucocorticoid Hormones on Pain Sensitivity: Involvement of Glucocorticoid and Mineralocorticoid Receptors
Glucocorticoid hormones are widely used in the clinic as analgesic and anti-inflammatory drugs for various types of pain. The actions of...
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The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice
Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal...
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Neuroendocrine-immune Interactions in Major Depressive Disorder: Glucocorticoids and Glucocorticoid Receptors
Major depressive disorder is a leading cause of disability worldwide; therefore, effective treatment options are crucial. However, due to the highly...
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Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells and natural inhibitors of adaptive immunity. Intracellular...
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Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays
Synthetic glucocorticoids (GCs) have been widely used in the treatment of a broad range of inflammatory diseases, but their clinic use is limited by...
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CLOCK, SIRT1, and HDAC2 Knockdown along with Melatonin Intervention Significantly Decreased the Level Glucocorticoid Receptor
AbstractInfantile spasm (IS) is a common catastrophic epilepsy syndromes occurred in infancy and associated with glucocorticoid release, but its...
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Role of histamine H4 receptor in the anti-inflammatory pathway of glucocorticoid-induced leucin zipper (GILZ) in a model of lung fibrosis
IntroductionThis study investigates the interactions between histaminergic system and glucocorticoid-induced leucin zipper (GILZ) in the inflammatory...
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a...
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A Genomic Study of the Japanese Population Focusing on the Glucocorticoid Receptor Interactome Highlights Distinct Genetic Characteristics Associated with Stress Response
All living organisms have been programmed to maintain a complex inner equilibrium called homeostasis, despite numerous adversities during their...
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Glucocorticoid Receptor/HCN4 Channels Interaction in Spinal Dorsal Horn Participates in the Regulation of Neuropathic Pain after Peripheral Nerve Injury in Rats
We studied the interaction between glucocorticoid receptor (GR) and HCN4 channels in the rat model of spared nerve injury (SNI) in Sprague-Dawley...
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Possible Correction of Impairments to the Glucocorticoid System of the Rat Hippocampus Induced by Prenatal Hypoxia
Abstract —Here, we studied the neuroprotective effect of triple moderate hypobaric hypoxia (3MHH) applied on days 8–10 of postnatal development on the...
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Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study
IntroductionOwing to controversy information surrounds effect of glucocorticoids on the evolution of COVID-19, we evaluate the effects of outpatient...
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FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice
Diabetic cognitive impairment (DCI) is a common diabetic complication characterized by learning and memory deficits. In diabetic patients,...
