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The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain
BackgroundThe glycinergic system plays an important inhibitory role in the mouse central nervous system, where glycine controls the excitability of...
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Outcomes of two different unbalanced segregations from a maternal t(4;10)(q33;p15.1) translocation
BackgroundUnbalanced translocations can cause developmental delay (DD), intellectual disability (ID), growth problems, dysmorphic features, and...
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Identifying Alzheimer’s genes via brain transcriptome map**
BackgroundAlzheimer’s disease (AD) is one of the most common neurodegenerative disorders characterized by progressive decline in cognitive function....
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Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
In the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and diabetic neuropathic pain;...
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A Molecular Biomarker-Based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms
Approximately 30% of COVID-19 cases may experience chronic symptoms, known as post-COVID-19 syndrome (PCS). Common PCS symptoms can include fatigue,...
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Glycine is a competitive antagonist of the TNF receptor mediating the expression of inflammatory cytokines in 3T3-L1 adipocytes
ObjectiveTo determine the involvement of TNF-α and glycine receptors in the inhibition of pro-inflammatory adipokines in 3T3-L1 cells.
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Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases
Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural functions during early development...
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Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
BackgroundAlzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) are three nervous system diseases that partially overlap...
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Cytogenomic characterization of 1q43q44 deletion associated with 4q32.1q35.2 duplication and phenotype correlation
BackgroundMicrodeletion of 1q43q44 causes a syndrome characterized by intellectual disability (ID), speech delay, seizures, microcephaly (MIC),...
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When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
BackgroundDuring embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast...
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Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening
In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including...
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The functions of repressor element 1-silencing transcription factor in models of epileptogenesis and post-ischemia
Epilepsy is a debilitating neurological disorder characterised by recurrent seizures for which 30% of patients are refractory to current treatments....
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The Genetic Basis of Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a microvascular complication of progressive renal decline in patients with diabetes, which is the leading cause of...
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Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to...
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LTBP1 plays a potential bridge between depressive disorder and glioblastoma
BackgroundGlioblastoma multiforme (GBM) is the most malignant tumor in human brain. Diagnosis and treatment of GBM may lead to psychological...
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The molecular neurobiology of chronic pain–induced depression
The increasing number of individuals with comorbidities poses an urgent need to improve the management of patients with multiple co-existing...
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microRNA and mRNA profiles in the amygdala are associated with stress-induced depression and resilience in juvenile mice
ObjectivesMajor depressive disorder characterized as recurrent negative mood is one of the prevalent psychiatric diseases. Chronic stress plus lack...
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Identification and analysis of long non-coding RNA related miRNA sponge regulatory network in bladder urothelial carcinoma
BackgroundThe aim of this study was to investigate the regulatory network of lncRNAs as competing endogenous RNAs (ceRNA) in bladder urothelial...
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Identification and ranking of recurrent neo-epitopes in cancer
BackgroundImmune escape is one of the hallmarks of cancer and several new treatment approaches attempt to modulate and restore the immune system’s...
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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading...
