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Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
BackgroundThe proliferation ability and autophagy level of pulmonary artery endothelial cells (PAECs) play an important role in promoting the...
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In Silico Genome-Wide Mining and Analysis of Terpene Synthase Gene Family in Hevea Brasiliensis
Terpene synthases (TPSs) catalyze terpenoid synthesis and affect the intracellular isopentenyl diphosphate (IPP) and dimethylallyl diphosphate...
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Therapeutic Significance of Tanshinone
Danshen, the dried root of Salvia miltiorrhiza, has been used for thousands of years as a traditional Chinese remedy, mainly for the treatment of...
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Statins and prostate cancer—hype or hope? The biological perspective
Growing evidence suggests that men prescribed a statin for cholesterol control have a lower risk of advanced prostate cancer (PCa) and improved...
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Immunomodulatory Role of Terpenoids and Phytosteroids
The immune system in vertebrates comprises a complex and sophisticated defense system and is traditionally divided in two types: innate immunity and...
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Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
This study compiles the main hypotheses involved in the etiopathogenesis of medication-related osteonecrosis of the jaw (MRONJ). A narrative review...
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Chemistry of Coleus forskohlii Briq.
Diterpenoid, forskolin is extracted from the roots of Coleus forskohlii Briq. (Syn. C. barbatus Benth. Lamiaceae). This species is the only source of...
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Bioprospection and Clinical Investigations of Immunomodulatory Molecules
The immune system, a complex network that guarantees protection against infections, plays an important role in the homeostasis of organs and tissues....
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Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics
Kaempferia species have contained various crucial ethnobotanical features, and are being used as traditional folk medicines in some Southeast Asia....
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Pathway Engineering for Beta-Carotene and Carotenoid Biosynthesis in Y. lipolytica
β-carotene is an increasingly sought-after organic pigment with antioxidant properties and a vitamin precursor. Yarrowia lipolytica, though unable to...
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Functional significance of cholesterol metabolism in cancer: from threat to treatment
Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a...
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Deciphering putative protein profile of a photomorphogenic high pigment mutant of Solanum lycopersicum (hp-1) by high-throughput LC–MS/MS analysis
The mutant hp-1 is a photomorphogenic high pigment tomato mutant. It has high commercial significance as a source of non-transgenic lycopene-rich...
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Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer
BackgroundOvarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the...
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Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery
Tigliane and daphnane diterpenoids are characteristically distributed in plants of the Thymelaeaceae family as well as the Euphorbiaceae family and...
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Biochemical Changes in the Local Onco-Sphere
The biochemical local onco-sphere changes as cancer grows, especially in the metabolic pathways of cancer cells. In cancer, formation and elimination...
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Regulation of Small GTPase Prenylation in the Nervous System
Mevalonate pathway inhibitors have been extensively studied for their roles in cholesterol depletion and for inhibiting the prenylation and...
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Tomato (Lycopene and β-Carotene) and Cancer
Consuming fruits and vegetables regularly is able to decrease the risks of cancer, increase longevity and improve the quality of life. Among them,...
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Enzymatic studies on aromatic prenyltransferases
Aromatic prenyltransferases (PTases), including ABBA-type and dimethylallyl tryptophan synthase (DMATS)-type enzymes from bacteria and fungi, play...
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Statins: a repurposed drug to fight cancer
As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit...
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Metabolic and Enzyme Engineering for the Microbial Production of Anticancer Terpenoids
Terpene or terpenoid or isoprenoid represents the largest class of secondary metabolites and has a variety of applications in food, fragrance, and...