Search
Search Results
-
Geniposide Alleviates Neuropathic Pain in CCI Rats by Inhibiting the EGFR/PI3K/AKT Pathway And Ca2+ Channels
Neuropathic pain (NP) is a common disorder among individuals worldwide, but there is still no effective treatment for NP. The EGFR pathway promotes...
-
Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice
Asperuloside (ASP) and geniposide (GP) are iridoids that have shown various biological properties, such as reduction of inflammation, oxidative...
-
Geniposide augments apoptosis in fibroblast-like synoviocytes by restoring hypoxia-enhanced JNK-BNIP3-mediated autophagy
BackgroundAs the main effector cells of chronic inflammation and hyperplasia of synovium, fibroblast-like synoviocytes (FLSs) show abnormal...
-
Geniposide ameliorates chronic unpredictable mild stress induced depression-like behavior through inhibition of ceramide-PP2A signaling via the PI3K/Akt/GSK3β axis
BackgroundDepression is a severe mental disorder. Unfortunately, more than half of patients with major depression disorder cannot achieve remission...
-
A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synovium
ObjectiveThe excessive proliferation of fibroblast-like synoviocytes (FLSs) is a key inducement for the occurrence and development of rheumatoid...
-
The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN
Rheumatoid arthritis (RA) is a systemic immune disease characterized by joint inflammation and pannus. The nascent pannus contributes to synovial...
-
Geniposide-Loaded Liposomes for Brain Targeting: Development, Evaluation, and In Vivo Studies
Geniposide (GE) possesses excellent neuroprotective effects but with poor brain targeting and short half-life. Liposome was considered to have great...
-
Penta-acetyl Geniposide Suppresses Migration, Invasion, and Inflammation of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes Involving Wnt/β-Catenin Signaling Pathway
We previously reported that penta-acetyl geniposide ((Ac) 5 GP, an active derivative of geniposide) showed anti-arthritic effect on adjuvant-induced...
-
Baicalin and Geniposide Inhibit Polarization and Inflammatory Injury of OGD/R-Treated Microglia by Suppressing the 5-LOX/LTB4 Pathway
Cerebral ischemia causes severe neurological disorders and neuronal dysfunction. Baicalin (BC), geniposide (GP), and their combination (BC/GP) have...
-
Geniposide Alleviates Traumatic Brain Injury in Rats Via Anti-Inflammatory Effect and MAPK/NF-kB Inhibition
We aimed to investigate whether geniposide, a main component extracted from Gardenia jasminoides Ellis fruit, could exert neuroprotective functions...
-
The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway
The purpose of the present study was to elucidate the pharmacological effects of Geniposide (GEN) on high diet fed and streptozotocin (STZ)-caused...
-
The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review
Besides synthetic drugs, a wide variety of medicinal plants have been used for the prevention and management of various liver disorders. Generally,...
-
Pharmacology of Natural and Synthetic Phytoprotectants: Application and Consequences in Cancer Therapies
Cancer represents one of the most fatal health issues, claiming the lives of millions of people each year. Tumorous growths can develop in almost any...
-
Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies
BackgroundIntervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP), posing a significant socioeconomic burden. Recent studies...
-
Comparative Study on the Pharmacokinetics of Paeoniflorin, White Peony Root Water Extract, and Taohong Siwu Decoction After Oral Administration in Rats
Background and ObjectiveTaohong Siwu Decoction (TSD) is a classic traditional Chinese medicine (TCM) compound with pharmacological effects such as...
-
Inducibility of Metabolizing Enzymes
Metabolic enzyme inducibility is of major significance, because it plays an important role in the susceptibility of individuals to foreign...
-
Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry
AbstractThe fruits of Gardenia jasminoides Ellis are an important herb medicine in Traditional Chinese Medicine (TCM) and have been used for...
-
Terpenes in the management of chronic kidney disease
Chronic kidney disease (CKD) is a chronic and progressive systemic condition that characterizes irreversible alterations in the kidneys’ function and...
-
Therapeutic Effect of Penta-acetyl Geniposide on Adjuvant-Induced Arthritis in Rats: Involvement of Inducing Synovial Apoptosis and Inhibiting NF-κB Signal Pathway
Previous studies demonstrated that penta-acetyl geniposide ((Ac) 5 GP, an acetylated derivative of geniposide) exhibited better pharmacological...
