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Genetic ancestry and diagnostic yield of exome sequencing in a diverse population
It has been suggested that diagnostic yield (DY) from Exome Sequencing (ES) may be lower among patients with non-European ancestries than those with...
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Cross-ancestry genetic architecture and prediction for cholesterol traits
While cholesterol is essential, a high level of cholesterol is associated with the risk of cardiovascular diseases. Genome-wide association studies...
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Genetic Ancestry Inference for Pharmacogenomics
Genetic ancestry inference can be used to stratify patient cohorts and to model pharmacogenomic variation within and between populations. We provide...
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Genetic Ancestry and Accumulation of BIN1 Gene Risk Alleles Associated to Alzheimer’s Disease in Latin American Populations
BIN1 gene is the second highest associated locus to Alzheimer’s disease (AD). Association between genetic ancestry and susceptibility to AD have been...
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to...
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A multi-ancestry genetic study of pain intensity in 598,339 veterans
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality...
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PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry
BackgroundProstate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African...
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Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from...
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Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women
Breast cancer is the most common cancer among US Hispanics/Latinas; however, Hispanic/Latina women in the United States have historically shown a...
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Genetic ancestry and population structure of vaccinia virus
Vaccinia virus (VACV) was used for smallpox eradication, but its ultimate origin remains unknown. The genetic relationships among vaccine stocks are...
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Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis
Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve...
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Genomic supremacy: the harm of conflating genetic ancestry and race
BackgroundRecent studies have reignited the tinderbox of debate surrounding the use of race and ancestry in medicine. These controversial studies...
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Multi-ancestry polygenic mechanisms of type 2 diabetes
Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully...
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Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers
BackgroundLatin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observational studies have...
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Genomic Ancestry as Biomarkers
The influence of ethnicity on diabetic retinopathy has been studied for decades with controversial results. Different populations report different...
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Development of a culturally targeted chatbot to inform living kidney donor candidates of African ancestry about APOL1 genetic testing: a mixed methods study
Clinical chatbots are increasingly used to help integrate genetic testing into clinical contexts, but no chatbot exists for A polipoprotein L1 ( APOL1 )...
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Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank
Osteoarthritis is a common progressive joint disease. As no effective medical interventions are available, osteoarthritis often progresses to the end...
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Cross-ancestry genome-wide association studies of brain imaging phenotypes
Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely...
