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Gene conversion: a non-Mendelian process integral to meiotic recombination
Meiosis is undoubtedly the mechanism that underpins Mendelian genetics. Meiosis is a specialised, reductional cell division which generates haploid...
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The Role of Extensive Recombination in the Evolution of Geminiviruses
Mutation, recombination and pseudo-recombination are the major forces driving the evolution of viruses by the generation of variants upon which...
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Divergence and conservation of the meiotic recombination machinery
Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during meiosis. Meiotic...
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A signal-seeking Phase 2 study of olaparib and durvalumab in advanced solid cancers with homologous recombination repair gene alterations
PurposeTo determine the safety and efficacy of PARP plus PD-L1 inhibition (olaparib + durvalumab, O + D) in patients with advanced solid,...
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Knockout of Tyrosine Aminotransferase Gene by Homologous Recombination Arrests Growth and Disrupts Redox Homeostasis in Leishmania Parasite
Tyrosine aminotransferase is a well-characterized enzyme in the Leishmania parasite, but the role of TAT in the parasite functioning remains largely...
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A Recombination Suppressed Region of Sunflower (Helianthus annuus L.) Linkage Group 13 Covers Restoration of Fertility (Rf1) and Downy Mildew Resistance (Pl) Gene Clusters
AbstractA number of genes that control traits that are valuable for breeding introgressed from wild relatives, i.e., pollen-fertility restoration and...
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Multi-scale characterisation of homologous recombination deficiency in breast cancer
BackgroundHomologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor...
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Predicting recombination frequency from map distance
Map distance is one of the key measures in genetics and indicates the expected number of crossovers between two loci. Map distance is estimated from...
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Differential expression of meiosis and homologous recombination-related genes in the life cycle of Trypanosoma cruzi
Trypanosoma cruzi has a complex life cycle consisting of four morphological and distinct biological stages. Although some authors suggest that T. cruzi ...
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Recombination analysis on the receptor switching event of MERS-CoV and its close relatives: implications for the emergence of MERS-CoV
BackgroundPlMERS-CoV is a coronavirus known to cause severe disease in humans, taxonomically classified under the subgenus Merbecovirus. Recent...
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Recombination map tailored to Native Hawaiians may improve robustness of genomic scans for positive selection
Recombination events establish the patterns of haplotypic structure in a population and estimates of recombination rates are used in several...
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Predicting recombination suppression outside chromosomal inversions in Drosophila melanogaster using crossover interference theory
Recombination suppression in chromosomal inversion heterozygotes is a well-known but poorly understood phenomenon. Surprisingly, recombination...
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Substantial viral diversity in bats and rodents from East Africa: insights into evolution, recombination, and cocirculation
BackgroundZoonotic viruses cause substantial public health and socioeconomic problems worldwide. Understanding how viruses evolve and spread within...
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Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families
It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC)...
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Intrachromosomal Recombination in Yeast
Spontaneous and induced mitotic recombinations are driven by lesions such as single-strand nicks and gaps and double-strand breaks in the genome. For...
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Genetic diversity, reassortment, and recombination of mammalian orthoreoviruses from Japanese porcine fecal samples
Mammalian orthoreoviruses (MRVs) are non-enveloped double-stranded RNA viruses with a broad host range. MRVs are prevalent worldwide, and in Japan,...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma
BackgroundEndemic Burkitt lymphoma (eBL) is potentiated through the interplay of Epstein Barr virus (EBV) and holoendemic Plasmodium falciparum ...
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CircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair
BackgroundRadiation therapy stands to be one of the primary approaches in the clinical treatment of malignant tumors. Nasopharyngeal Carcinoma, a...
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SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation
BackgroundNeoadjuvant radiotherapy has been used as the standard treatment of colorectal cancer (CRC). However, radiotherapy resistance often results...
