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Gene Delivery to Chondrocytes
Delivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the...
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Microfluidic Approaches for Gene Delivery and Therapy
Gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) have been developed to target a gene into...
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Gene Therapy in Molecular Biology and Drug Delivery
The objective of gene therapy is to manipulate/modify the gene expression or modify living cell characteristics for therapeutic utilization. It aims...
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Targeted gene delivery systems for T-cell engineering
T lymphocytes are indispensable for the host systems of defense against pathogens, tumors, and environmental threats. The therapeutic potential of...
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Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of...
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ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer
Metal–organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug delivery and gene therapy...
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Efficient and scalable gene delivery method with easily generated cationic carbon dots
Gene delivery is a complex process with several challenges when attempting to incorporate genetic material efficiently and safely into target cells....
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Empowering gene delivery with protein engineering platforms
The repertoire of therapeutic proteins has been substantially augmented by molecular engineering approaches, which have seen remarkable advancement...
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Revisiting of Properties and Modified Polyethylenimine-Based Cancer Gene Delivery Systems
A new era of medical technology in cancer treatment is a directly specific modification of gene expression in tumor cells by nucleic acid delivery....
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Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease
ObjectiveCurrent gene therapy of inherited retinal diseases is achieved mainly by subretinal injection, which is invasive with severe adverse...
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Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2
ObjectiveThe aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and...
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Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery
Infections with the human immunodeficiency virus type 1 (HIV-1) are incurable due the long-lasting, latent viral reservoir. The shock-and-kill cure...
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In Vivo Viral Gene Delivery to Manipulate Functional Properties of AMPA Receptors in Oligodendrocyte Lineage Cells
Delivery or deletion of genes of interest in the nervous system of animals in vivo is a complex and difficult task. While genetic manipulations can...
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AAV-Mediated Gene Delivery to Mouse Brown Adipose Tissue
Recombinant adeno-associated virus (AAV) vectors are attractive vehicles for gene therapy. Yet targeting adipose tissue is still a challenging task....
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Nano–Bio Interactions: Exploring the Biological Behavior and the Fate of Lipid-Based Gene Delivery Systems
Gene therapy for many diseases is rapidly becoming a reality, as demonstrated by the recent approval of various nucleic acid-based therapeutics....
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Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery
Necrosis is a common feature of solid tumours that offers a unique opportunity for targeted cancer therapy as it is absent from normal healthy...
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Transdermal delivery for gene therapy
Gene therapy is a critical constituent of treatment approaches for genetic diseases and has gained tremendous attention. Treating and preventing...
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Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing system has been a major technological breakthrough that...
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Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson’s disease treatment
BackgroundNeurodegenerative diseases, including Parkinson's disease, Amyotropic Lateral Sclerosis (ALS) and Alzheimer's disease, present significant...
