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In Silico Prediction and Molecular Docking of SNPs in NRP1 Gene Associated with SARS-COV-2
Neuropilin-1 (NRP1) which is a main transmembrane cell surface receptor acts as a host cell mediator resulting in increasing the SARS-Cov-2...
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Identification of fatty acids synthesis and metabolism-related gene signature and prediction of prognostic model in hepatocellular carcinoma
BackgroundFatty acids synthesis and metabolism (FASM)-driven lipid mobilization is essential for energy production during nutrient shortages....
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PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia
The deregulation of BCL2 family proteins plays a crucial role in leukemia development. Therefore, pharmacological inhibition of this family of...
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Variability of polygenic prediction for body mass index in Africa
BackgroundPolygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits...
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PdmIRD: missense variants pathogenicity prediction for inherited retinal diseases in a disease-specific manner
Accurate discrimination of pathogenic and nonpathogenic variation remains an enormous challenge in clinical genetic testing of inherited retinal...
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Calibrated prediction intervals for polygenic scores across diverse contexts
Polygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields. We show that PGS performance varies...
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Genomic prediction of cotton fibre quality and yield traits using Bayesian regression methods
Genomic selection or genomic prediction (GP) has increasingly become an important molecular breeding technology for crop improvement. GP aims to...
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AttSiOff: a self-attention-based approach on siRNA design with inhibition and off-target effect prediction
Small interfering RNA (siRNA) is often used for function study and expression regulation of specific genes, as well as the development of small...
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Molecular Prediction and Correlation of the Structure and Function of Universal Stress Protein A (UspA) from Salmonella Typhimurium
Salmonella Typhimurium (ST) is a zoonotic pathogen that can cause gastroenteritis in humans when they consume contaminated food or water. When...
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Gene based markers improve precision of genome-wide association studies and accuracy of genomic predictions in rice breeding
It is hypothesized that the genome-wide genic markers may increase the prediction accuracy of genomic selection for quantitative traits. To test this...
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Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from...
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In Silico Characterization of Pathogenic Homeodomain Missense Mutations in the PITX2 Gene
Paired homologous domain transcription factor 2 (PITX2) is critically involved in ocular and cardiac development. Mutations in PITX2 are consistently...
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Efficiency of pharmaceutical toxicity prediction in computational toxicology
The adverse effects and toxicity of chemical substances pose substantial challenges in drug discovery and environmental science. Their management,...
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Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data...
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Modeling Tox21 Data for Toxicity Prediction and Mechanism Deconvolution
Toxicology in the twenty-first century (Tox21) is a US federal collaborative program that develops high throughput in vitro assays to efficiently...
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Online Service with Automated Interpretation of Sequencing Data and Prediction of Pyrazinamide Resistance in Mycobacterium tuberculosis
Pyrazinamide plays an important role in the treatment of tuberculosis. However, the microbiological test for pyrazinamide resistance is more complex...
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The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men
Objectives. To analyze the role of genetic polymorphisms of matrix metalloproteinase ( MMP ) genes and their gene–gene and gene–environment...
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Artificial Intelligence and Computational Biology in Gene Therapy: A Review
One of the trending fields in almost all areas of science and technology is artificial intelligence. Computational biology and artificial...
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A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
BackgroundThe microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus...
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Polygenic prediction of preeclampsia and gestational hypertension
Preeclampsia and gestational hypertension are common pregnancy complications associated with adverse maternal and child outcomes. Current tools for...
