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Amyotrophic Lateral Sclerosis-Related Gene Interactions with Fat Mass and Obesity-Associated Gene
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by rapid progressive paralysis and death within a few...
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Amyotrophic Lateral Sclerosis-Related Gene Interactions with Fat Mass and Obesity-Associated Gene
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by rapid progressive paralysis and death within a few...
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Predicting genes from phenotypes using human phenotype ontology (HPO) terms
The interpretation of genomic variants following whole exome sequencing (WES) can be aided using human phenotype ontology (HPO) terms to standardize...
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Gene function annotations for the maize NAM founder lines
ObjectivesWe annotated the latest published sequences of the 26 Zea mays Nested Association Map** (NAM) founder lines using GOMAP, the Gene...
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Dissecting the Immune System through Gene Regulation
The immune system plays a dual role in human health, functioning both as a protector against pathogens and, at times, as a contributor to disease....
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GeneSelectML: a comprehensive way of gene selection for RNA-Seq data via machine learning algorithms
AbstractSelection of differentially expressed genes (DEGs) is a vital process to discover the causes of diseases. It has been shown that modelling of...
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The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types
The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge...
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Identification of RRM2 as a key ferroptosis-related gene in sepsis
ObjectiveSepsis and sepsis-associated organ failure are devastating conditions for which there are no effective therapeutic agent. Several studies...
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Systems biology approach: identification of hub genes, signaling pathways, and molecular docking of COL1A1 gene in cervical insufficiency
The collagen type I alpha 1 ( COL1A1, OMIM #120,150) gene, encoding the alpha-1 chain of type I collagen (UniProt #P02452), plays a key role in...
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Identification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Liver hepatocellular carcinoma (LIHC) is a malignant cancer with high incidence and poor prognosis. To investigate the correlation between hub genes...
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NGS and phenotypic ontology-based approaches increase the diagnostic yield in syndromic retinal diseases
Syndromic retinal diseases (SRDs) are a group of complex inherited systemic disorders, with challenging molecular underpinnings and clinical...
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Identification of potential biological processes and key genes in diabetes-related stroke through weighted gene co-expression network analysis
BackgroundType 2 diabetes mellitus (T2DM) is an established risk factor for acute ischemic stroke (AIS). Although there are reports on the...
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Investigation of Potential Crucial Genes and Key Pathways in Keratoconus: An Analysis of Gene Expression Omnibus Data
Keratoconus is one of the most common causes leading to visual impairment in young adult population. The pathogenesis of keratoconus remains poorly...
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SNPs Classification and Terminology: dbSNP Reference SNP (rs) Gene and Consequence Annotation
This chapter introduces the NCBI Single Nucleotide Polymorphism database (dbSNP), an important resource for understanding human variation and...
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Retinoblastoma gene expression profiling based on bioinformatics analysis
BackgroundRetinoblastoma (RB) is frequently occurring malignant tumors that originate in the retina, and their exact cause and development mechanisms...
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Gene expression profiles in COVID-19-associated tracheal stenosis indicate persistent anti-viral response and dysregulated retinol metabolism
IntroductionCoronavirus disease 2019 (COVID-19)-associated tracheal stenosis (COATS) may occur as a result of prolonged intubation during COVID-19...
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Gene expression analysis reveals diabetes-related gene signatures
BackgroundDiabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either...
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Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis
ObjectiveMice are routinely utilized as animal models of drug-induced liver injury (DILI), however, there are significant differences in the...
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Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain’s major cell types and are responsible for maintaining neuronal homeostasis via regulating the extracellular...
