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1. Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation

   Desmoplastic infantile astrocytoma (DIA) is rare, cystic and solid tumor of infants usually found in superficial cerebral hemispheres. Although DIA...

   Javier Megías, Teresa San-Miguel, ... Concha López-Ginés in Acta Neuropathologica Communications

   Article Open access 20 June 2022
   

2. Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences

   Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical...

   Matthew D. Wood, Carol Beadling, ... Christopher Corless in Acta Neuropathologica Communications

   Article Open access 05 September 2023
   

3. Malignant Spinal Tumors

   MalignantMalignant spinal tumors constitute around 22% of all primary spinal tumors. The most common location of metastasesMetastases to the spinal...

   Mohammad Hassan A. Noureldine, Nir Shimony, George I. Jallo in Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2

   Chapter 2023
   

4. Benign Glioma

   BenignBenign gliomaGliomas broadly refers to a heterogeneousHeterogeneous group of slow-growing glial tumors with low proliferative rates and a more...

   Peter B. Wu, Anna C. Filley, ... Jeffrey N. Bruce in Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2

   Chapter 2023
   

5. Introduction to Cell Signaling Pathways and Brain Tumors

   Cell signaling is the process by which cells coordinate and communicate with other cells, allowing cells to act in the correct way in response to...

   Mehdi Hayat Shahi in Role of Signaling Pathways in Brain Tumorigenesis

   Chapter 2023
   

6. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction

   As one of the global concerns, cancers, including brainBrain and spinal cord tumorsSpinal cord tumors, are responsible for mortalities and...

   Arad Iranmehr, Mohamad Namvar, ... Sara Hanaei in Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1

   Chapter 2023
   

7. Pediatric central nervous system tumor with CIC::LEUTX fusion: a diagnostic challenge

   Yanghao Hou, Yanru Du, ... Wanming Hu in Acta Neuropathologica Communications

   Article Open access 27 June 2024
   

8. RNA Sequencing of Intraoperative Peritumoral Tissues Reveals Potential Pathways Involved in Glioma-Related Seizures

   Tumor-induced changes in the peritumoral neocortex play a crucial role in generation of seizures. This study aimed to investigate the molecular...

   Krishan Kumar, Vivek Dubey, ... Jyotirmoy Banerjee in Journal of Molecular Neuroscience

   Article 02 June 2023
   

9. Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas

   Diffuse gliomas are the most prevalent malignant primary brain tumors in adults and remain incurable despite standard therapy. Tumor recurrence is...

   Sandra Ferreyra Vega, Thomas Olsson Bontell, ... Helena Carén in Acta Neuropathologica Communications

   Article Open access 04 February 2023
   

10. Subependymal giant cell astrocytoma: an unexpected finding during a forensic autopsy

    Jessica Vanhaebost, Julie Lelotte in Acta Neurologica Belgica

    Article 18 June 2019
    

11. Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors

    Accumulating data shows that altered metabolic activity contributes to glioma development. Recently, modulation of SSADH (succinic semialdehyde...

    Christina Piperi, Mirca S. Saurty-Seerunghen, ... Penelope Korkolopoulou in Neurotherapeutics

    Article 28 March 2023
    

12. Methodological and analytical considerations for intra-operative microdialysis

    Background

    Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in...

    Cecile Riviere-Cazaux, Karishma Rajani, ... Terry C. Burns in Fluids and Barriers of the CNS

    Article Open access 19 December 2023
    

13. Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based map**

    Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) neoplasm in adults, and has an almost universally poor...

    James F. Lyon, Varshini Vasudevaraja, ... Mariano S. Viapiano in Acta Neuropathologica Communications

    Article Open access 30 June 2021
    

14. Deep histopathology genotype–phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb

    Focal cortical dysplasia type II (FCDII) is the most common cause of drug-resistant focal epilepsy in children. Herein, we performed a deep...

    Jonas Honke, Lucas Hoffmann, ... Ingmar Blümcke in Acta Neuropathologica Communications

    Article Open access 09 November 2023
    

15. High frequency of PDGFRA and MUC family gene mutations in diffuse hemispheric glioma, H3 G34-mutant: a glimmer of hope?

    Background

    Diffuse hemispheric glioma H3 G34-mutant (G34-DHG) is a new type of pediatric-type diffuse high-grade glioma in the fifth edition of the...

    Wanming Hu, Hao Duan, ... Yonggao Mou in Journal of Translational Medicine

    Article Open access 02 February 2022
    

16. Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study

    Background

    Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively...

    Charles A. Stiller, Anita M. Bayne, ... Paul Chumas in BMC Cancer

    Article Open access 11 February 2019
    

17. Prognostic factors in patients with glioblastoma multiforme: focus on the pathologic variants

    The aim of this study was to offer predicting factors for survival in adult patients with glioblastoma multiforme. 153 consecutive patients with...

    Ehsan Alimohammadi, Seyed Reza Bagheri, ... Alireza Abdi in Acta Neurologica Belgica

    Article 20 June 2019
    

18. Diagnostic accuracy of ¹³N-ammonia PET, ¹¹C-methionine PET and ¹⁸F-fluorodeoxyglucose PET: a comparative study in patients with suspected cerebral glioma

    Background

    The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission...

    Qiao He, Linqi Zhang, ... **angsong Zhang in BMC Cancer

    Article Open access 08 April 2019
    

19. Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

    Background

    We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been...

    Charlotte Aaberg-Jessen, Mia D. Sørensen, ... Bjarne W. Kristensen in BMC Cancer

    Article Open access 09 March 2018
    

20. The Auditory System

    The ear or vestibulocochlear organ is composed of external, middle and inner parts. The external ear consists of the auricle and the external...

    Hans J. ten Donkelaar, Kimitaka Kaga in Clinical Neuroanatomy

    Chapter 2020