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Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study
BackgroundMetastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some...
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Chemoradiotherapy with concurrent durvalumab for the palliative treatment of oligometastatic oesophageal and gastrooesophageal carcinoma with dysphagia: a single arm phase II clinical trial (PALEO, sponsored by the Australasian Gastro-Intestinal Trials Group)
BackgroundOesophageal and gastrooesophageal junction (GOJ) carcinoma frequently present with dysphagia and de novo metastatic disease. There is scope...
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First Molecular Identification of Ancylostoma Species in Dogs in a Rural Tea Estate Community in Sri Lanka and the Detection of Other Zoonotic Gastro-intestinal Parasites
PurposeAncylostoma spp. causing canine hookworm infections are distributed worldwide with a high prevalence in the South Asian region. Here, we...
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Comment on Balsamo et al.: Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature
The publication by Balsamo and colleagues describes a patient with Birt-Hogg-Dubé syndrome and hyperplastic polyposis throughout the...
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The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads
Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the...
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Mechanism-Based Physiological Effects of Piperine: A Review
BackgroundPiperine is the piperidine alkaloid present in the fruits of Black pepper ( Piper nigrum ) and long pepper ( Piper longum ). It is a pungent...
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Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
BackgroundThe effects of fermented food consumption on the small intestine microbiome and its role on host homeostasis are largely uncharacterised as...
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Fish Acanthocephalans as Potential Human Pathogens
Purpose of ReviewAcanthocephalans attach to the gastro-intestinal mucosa of the host (mammals, birds, reptiles, amphibians, fish) by use of a...
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Development, Characterization and In Vitro Gastrointestinal Release of PLGA Nanoparticles Loaded with Full-Spectrum Cannabis Extracts
Cannabinoids, such as ∆ 9 -tetrahydrocannabinol (THC) and cannabidiol (CBD), are effective bioactive compounds that improve the quality of life of...
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Haploinsufficiencies of FOXF1, FOXC2 and FOXL1 genes originated from deleted 16q24.1q24.2 fragment related with alveolar capillary dysplasia with misalignment of pulmonary veins and lymphedema-distichiasis syndrome: relationship to phenotype
ObjectiveWe describe a fetus with a 2.12-Mb terminal deleted fragment in 16q associated with alveolar capillary dysplasia with misalignment of...
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Healthcare-associated infections in Dutch hospitals during the COVID-19 pandemic
BackgroundDuring the COVID-19 pandemic hospitals reorganized their resources and delivery of care, which may have affected the number of...
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The immunology of Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder which affects 6.1 million people worldwide. The neuropathological...
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Polyphenols: a route from bioavailability to bioactivity addressing potential health benefits to tackle human chronic diseases
Chronic pathologies or non-communicable diseases (NCDs) include cardiovascular diseases, metabolic syndrome, neurological diseases, respiratory...
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Anisakiasis
Anisakiasis, caused mostly by Anisakis spp., is a globally emerging seafood-borne zoonotic disease, which remains largely underdiagnosed. The marine...
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Anisakiasis
Anisakiasis refers to the zoonotic disease provoked in humans by the accidental ingestion of the larvae of Anisakis spp. infecting fish or squid and...
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Toxicity management of regorafenib in patients with gastro-intestinal stromal tumour (GIST) in a tertiary cancer centre
BackgroundRegorafenib is a multi-kinase inhibitor approved as third line treatment for metastatic GIST. Dose limiting toxicities are frequently seen...
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Satiety: a gut–brain–relationship
Many hormones act on the hypothalamus to control hunger and satiety through various pathways closely associated with several factors. When food is...
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Drugs Affecting Gastrointestinal Functions
The digestive system in humans is the mechanism that the body uses to carry out digestion. Food is ingested by the digestive system, which is...
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30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
It is 30 years since the first diagnostic cancer predisposition gene (CPG) test in the Manchester Centre for Genomic Medicine (MCGM), providing...
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Probiotic Administration for the Prevention and Treatment of Gastrointestinal, Metabolic and Neurological Disorders
The interest in the intestinal microbiota of humans has increased in the last 20 years and significant advances have been achieved with regard to its...