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Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study
BackgroundMetastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some...
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Li Fraumeni Syndrome predisposes to gastro-esophageal junction tumours
Li-Fraumeni Syndrome (LFS), caused by germline pathogenic variants in TP53 , predisposes to a wide range of young-onset malignancies, particularly...
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Chemoradiotherapy with concurrent durvalumab for the palliative treatment of oligometastatic oesophageal and gastrooesophageal carcinoma with dysphagia: a single arm phase II clinical trial (PALEO, sponsored by the Australasian Gastro-Intestinal Trials Group)
BackgroundOesophageal and gastrooesophageal junction (GOJ) carcinoma frequently present with dysphagia and de novo metastatic disease. There is scope...
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Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma
Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine differentiation, can arise in various organs. NENs have been divided into...
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Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
BackgroundThe effects of fermented food consumption on the small intestine microbiome and its role on host homeostasis are largely uncharacterised as...
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First Molecular Identification of Ancylostoma Species in Dogs in a Rural Tea Estate Community in Sri Lanka and the Detection of Other Zoonotic Gastro-intestinal Parasites
PurposeAncylostoma spp. causing canine hookworm infections are distributed worldwide with a high prevalence in the South Asian region. Here, we...
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Comment on Balsamo et al.: Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature
The publication by Balsamo and colleagues describes a patient with Birt-Hogg-Dubé syndrome and hyperplastic polyposis throughout the...
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The effect of physical stability and modified gastrointestinal tract behaviour of resveratrol-loaded NLCs encapsulated alginate beads
Nanostructured lipid carriers (NLC) have low storage and gastrointestinal stability, limiting their applicability. The work aimed to elevate the...
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Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers
The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)- and/or carbapenemase-producing Enterobacterales ( Ent ) has reached...
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Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models
BackgroundThe widespread use of nano-biomaterials (NBMs) has increased the chance of human exposure. Although ingestion is one of the major routes of...
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Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli (ETEC) K88-infected piglet
Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating properties. In this study, we built...
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Exposure to nonanoic acid alters small intestinal neuroendocrine tumor phenotype
BackgroundSmall intestinal neuroendocrine tumors (SI-NET) are highly differentiated and genetically stable malignant tumors, yet they often present...
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Mechanism-Based Physiological Effects of Piperine: A Review
BackgroundPiperine is the piperidine alkaloid present in the fruits of Black pepper ( Piper nigrum ) and long pepper ( Piper longum ). It is a pungent...
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Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide
PurposeOral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides....
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Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their...
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Intestinal Protozoa: Their Role as Human Pathogens and Zoonoses
Intestinal protozoa are single-celled eukaryotic microorganisms with nearly 10,000 species being parasitic in many invertebrates and most...
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Fish Acanthocephalans as Potential Human Pathogens
Purpose of ReviewAcanthocephalans attach to the gastro-intestinal mucosa of the host (mammals, birds, reptiles, amphibians, fish) by use of a...
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Satiety: a gut–brain–relationship
Many hormones act on the hypothalamus to control hunger and satiety through various pathways closely associated with several factors. When food is...
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Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial
BackgroundPre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing...
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Development, Characterization and In Vitro Gastrointestinal Release of PLGA Nanoparticles Loaded with Full-Spectrum Cannabis Extracts
Cannabinoids, such as ∆ 9 -tetrahydrocannabinol (THC) and cannabidiol (CBD), are effective bioactive compounds that improve the quality of life of...
