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Oligodendroglial Gap Junction Communication in CNS Myelination and Demyelination
In the previous chapter, we discussed the physiological importance of gap junction proteins, namely connexins (Cxs), and the importance of astrocytes...
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Intercellular Communication in Cancer
Junctional complexes play a central role in maintaining tissue hemostasis. The barrier function of epithelial cells, that maintain tissues coherence...
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Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic association
BackgroundRecently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed important cellular and functional features of Alzheimer's disease (AD),...
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Hyperglycaemia-induced impairment of the autorhythmicity and gap junction activity of mouse embryonic stem cell-derived cardiomyocyte-like cells
Diabetes mellitus with hyperglycaemia is a major risk factor for malignant cardiac dysrhythmias. However, the underlying mechanisms remain unclear,...
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Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production
Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension. Most have gain-of-function somatic mutations of ion channels...
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Gap Junctions and Cardiac Impulse Propagation. New Aspects of Arrhythmogenesis and Antiarrhythmic Agents Targeting Gap Junctions
A basic phenomenon of the heart is its regular beating and a directed propagation of the electrical impulse which, during the plateau phase of the...
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DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released from host cells as a result of cell death or damage. The...
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Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice
BackgroundPostoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has...
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Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation
Major depression disorder (MDD) is a neuropsychiatric disorder associated with a high suicide rate and a higher disability rate than any other...
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Gap Junctions and Electric Synapses
Signal transmission between neurons is mediated in multiple distinct ways. In the adult brain, transmission via neurotransmitters (chemical synapsis)...
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Rescuers from the Other Shore: Intercellular Mitochondrial Transfer and Its Implications in Central Nervous System Injury and Diseases
As the powerhouse and core of cellular metabolism and survival, mitochondria are the essential organelle in mammalian cells and maintain cellular...
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Spatiotemporal heterogeneity of LMOD1 expression summarizes two modes of cell communication in colorectal cancer
Cellular communication (CC) influences tumor development by mediating intercellular junctions between cells. However, the role and underlying...
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Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by...
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The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell–cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway
Connexin 43 (Cx43) is the most important protein in the gap junction channel between cardiomyocytes. Abnormalities of Cx43 change the conduction...
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Neurons, Macrophages, and Glia: The Role of Intercellular Communication in the Enteric Nervous System
Neurons of the enteric nervous system (ENS) are the primary controllers of gastrointestinal functions. Although the ENS has been the central focus of...
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Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson’s disease
Parkinson’s disease (PD) is a neurological disorder that affects the movement of the human body. It is primarily characterized by reduced dopamine...
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Intercellular communication and ion channels in neuropathic pain chronicization
BackgroundNeuropathic pain is caused by primary lesion or dysfunction of either peripheral or central nervous system. Due to its complex...
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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria
As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many...
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Tight Junction-Related CLDN5 and CLDN6 Genes, and Gap Junction-Related GJB6 and GJB7 Genes Are Somatically Mutated in Gastric and Colorectal Cancers
Tight junction and gap junction are major cell junctions that play important roles in cellular communication and structural integrity. Alterations of...
