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MiR-1275 Targeting SPARC Promotes Gambogic Acid-Induced Inhibition of Gastric Cancer
Gambogic acid (GA) has been observed to effectively impede the progression of numerous types of cancers. In this study, we investigated the effects...
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Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2
Cancer cells rely on heat shock proteins (HSPs) for growth and survival. Especially HSP90 has multiple client proteins and plays a critical role in...
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Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway
ObjectiveIn this work, we investigated the effects of gambogic acid (GA) on lipopolysaccharide (LPS)-induced apoptosis and inflammation in a cell...
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Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. Gambogic acid has been reported to have anti-inflammatory effect....
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A solvent-assisted active loading technology to prepare gambogic acid and all-trans retinoic acid co-encapsulated liposomes for synergistic anticancer therapy
Liposomal drug delivery has become an established technology platform to deliver dual drugs to produce synergistic effects and reduce the adverse...
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Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
BackgroundGambogic acid is a natural component isolated from gamboge that possesses anticancer properties. Our previous study suggested that gambogic...
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Multifaceted Molecular Targets of Anti-Inflammatory Agents from Ayurvedic Plants
The relationship between prolonged inflammation and the occurrence of different fatal diseases like cancer was first identified in the nineteenth...
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The growth inhibitory effect of gambogic acid on pancreatic cancer cells
Pancreatic cancer, the fourth most common cause of cancer-related deaths, is one of the most aggressive and devastating human malignancies with...
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IDO and TGF-β Inhibitors for the Treatment of Lung Cancer
Indoleamine-2,3-dioxygenase (IDO) is an enzyme that catalyzes the conversion of tryptophan to N-formylkynurenine, and it is the rate-limiting step in...
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Treatment with protocatechuic acid attenuates cisplatin-induced toxicity in the brain and liver of male Wistar rats
This study investigated the ameliorative effect of protocatechuic acid (PCA) in oxidative stress induced by cisplatin (CPL) in the brain and liver of...
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Natural products and the balancing act of autophagy-dependent/independent ferroptosis in cancer therapy
The control of biological cell death is essential for the body’s appropriate growth. The resistance of cells to the apoptotic process presents a new...
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Drug Development in the Field of Sphinogolipid Metabolism
Sphingolipids are the major lipid components on cellular membranes especially on lipid raft regions, intermediating various important biological...
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Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Plasticity of phenotypic traits refers to an organism’s ability to change in response to environmental stimuli. As a result, the response may alter...
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Paraptosis: a non-classical paradigm of cell death for cancer therapy
Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential strategy for cancer therapy. Paraptosis is a mode of...
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Physical and Analytical Techniques Used for the Characterization of Polymeric Micelles
Nanomedicines are notably the intriguing strategies for addressing diverse challenges allied with drug delivery. Polymeric micelles, a self-assembled...
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Targeting paraptosis in cancer: opportunities and challenges
Cell death can be classified into two primary categories: accidental cell death and regulated cell death (RCD). Within RCD, there are distinct...
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Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis
Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone tissue, resulting in joint...
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Conventional Nanosized Drug Delivery Systems for Cancer Applications
Clinical responses and tolerability of conventional nanocarriers (NCs) are sometimes different from those expected in anticancer therapy. Thus, new...
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The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues
The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain...
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Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer
Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide. Almost 70–80% of cases of BC are curable at the early...
