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Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice
BackgroundCholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we...
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AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells
BackgroundInflammatory injury of gallbladder mucosal epithelial cells affects the development of cholelithiasis, and aquaporin 3 ( AQP3 ) is an...
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Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study
We conducted a Mendelian randomization study to determine the potential causal associations of gallstone disease, diabetes, serum calcium,...
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Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis
BackgroundEpidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of develo**...
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Causal effects of gallstone disease on risk of gastrointestinal cancer in Chinese
BackgroundGallstone disease (GSD) is associated with a higher risk of gastrointestinal (GI) cancer. However, it is unclear whether the associations...
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Association of apolipoprotein B XbaI (rs693) polymorphism and gallstone disease risk based on a comprehensive analysis
BackgroundOur aim was to investigate the association between XbaI gene polymorphisms in the apolipoprotein B ( APOB ) gene and gallstone disease (GD)...
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Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses
The causal relationships between plasma metabolites and cholelithiasis/cholecystitis risks remain elusive. Using two-sample Mendelian randomization,...
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Altered absorptive function in the gall bladder during cholesterol gallstone formation is associated with abnormal NHE3 complex formation
Dysfunction of the Na + /H + exchanger 3 (NHE3) contributes to the formation of cholesterol gallstones. We aimed to investigate whether NHE3 dysfunction...
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Efficacy and safety of a novel topical agent for gallstone dissolution: 2-methoxy-6-methylpyridine
BackgroundAlthough methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for gallstone dissolution, its use is limited by its side...
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The association between apolipoprotein E and gallstone disease: an updated meta-analysis
BackgroundGallstone disease (GSD) is a common biliary tract disease worldwide. Previous studies have investigated the association of apolipoprotein E...
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Tissue proteome analysis for profiling proteins associated with lymph node metastasis in gallbladder cancer
Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC)....
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Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022
BackgroundEdwardsiella tarda is a member of Enterobacteriaceae isolated from freshwater and sea. E. tarda infection in humans commonly causes...
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Recent Advances in the Critical Role of the Sterol Efflux Transporters ABCG5/G8 in Health and Disease
Cardiovascular disease is characterized by lipid accumulation, inflammatory response, cell death, and fibrosis in the arterial wall and is the...
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Risk factors for pegylated liposomal doxorubicin-induced moderate to severe hand-foot syndrome in breast cancer patients: assessment of baseline clinical parameters
BackgroundHand-foot syndrome (HFS) is a side effect of skin related to pegylated liposomal doxorubicin (PLD) application. Moderate to severe...
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Drugs Affecting Gastrointestinal Functions
The digestive system in humans is the mechanism that the body uses to carry out digestion. Food is ingested by the digestive system, which is...
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The role of hypoxia-inducible factor 1α in hepatic lipid metabolism
AbstractChronic liver disease is a major public health problem with a high and increasing prevalence worldwide. In the progression of chronic liver...
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