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Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue
Parkinson’s disease (PD) is a progressive neurodegenerative disease of the brain due to degeneration of dopaminergic neurons in the substantia nigra...
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Graded Differentiation of Glioma in GSK-3 β: The Study and Analysis of the Expression Difference and Its Significance in the Endoplasmic Reticulum Stress Apoptosis Pathway
AbstractGlioma accounts for 80% of malignant central nervous system, with high incidence and extremely difficult to cure. However, for the role of ER...
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Cinnamaldehyde Regulates Insulin and Caspase-3 Signaling Pathways in the Sporadic Alzheimer’s Disease Model: Involvement of Hippocampal Function via IRS-1, Akt, and GSK-3β Phosphorylation
Insulin signaling disruption and caspase-3 cleavage play a pathologic role in Alzheimer’s disease (AD). Evidence suggested that cinnamaldehyde (Cin),...
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Proposed hypothesis of GSK-3 β inhibition for stimulating Wnt/β-catenin signaling pathway which triggers liver regeneration process
Almost every human organ has a poor ability to regenerate, notable exceptions are liver, skin, gut, etc. Molecular and cellular underpinnings of...
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α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks
In Parkinson’s disease, the dysfunction of the dopaminergic nigrostriatal tract involves the loss of function of dopaminergic neurons of the...
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Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats
RationaleΔ 9 -tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis and is responsible for cannabis-related neuropsychiatric...
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Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells
ObjectiveThe threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and...
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Exploring the Diverse Roles of GSK-3β Kinase in Alzheimer’s Disease
Alzheimer’s disease, a progressive neurodegenerative disorder, is a global health concern whose consequence affects an individual’s cognitive scores,...
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Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most prevalent form of age-related dementia. Even though a century has passed since the discovery of AD, the exact...
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GSK-3α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion
AbstractReperfusion after acute myocardial infarction further exaggerates cardiac injury and adverse remodeling. Irrespective of cardiac cell types,...
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Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways
BackgroundPirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the...
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GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis
Whether epigenetic modifications participate in the cell apoptosis after ischemic stroke remains unclear. Histone 3 tri-methylation at lysine 27...
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Glycogen Synthase Kinase-3 Inhibitors Block Morphine-Induced Locomotor Activation, Straub Tail, and Depression of Rearing in Mice Via a Possible Central Action
We investigated morphine-induced Straub’s tail reaction (STR) in mice pretreated with or without glycogen synthase kinase-3 (GSK-3) inhibitors...
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Mechanistic Implications of GSK and CREB Crosstalk in Ischemia Injury
Ischemia-reperfusion (IR) injury is a damage to an organ when the blood supply is less than the demand required for normal functioning, leading to...
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Corydaline alleviates Parkinson’s disease by regulating autophagy and GSK-3β phosphorylation
BackgroundJitai tablet, a traditional Chinese medicine, has a neuroprotective effect on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine...
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Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition
Myocardial hypertrophy is a pathological thickening of the myocardium which ultimately results in heart failure. We previously reported that...
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Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
BackgroundAbout 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need...
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Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway
BackgroundDiabetic encephalopathy is manifested by cognitive dysfunction. Salidroside, a nature compound isolated from Rhodiola rosea L , has the...
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Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis
Osthole is a natural coumarin substance that has an inhibitory effect on hepatic cancer, but its radiosensitization effect on hepatoma cells has not...
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Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
The circadian system is a conserved time-kee** machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and...
