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Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
Transcriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in the majority of brain tumors, including adult...
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Therapeutic Implication of Oxidative Stress Regulators in Drug-Resistant Cancers
Although initial clinical responses to current standard chemotherapies are often dramatic, a significant number of cancer patients develop drug...
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Therapeutic Implication of Oxidative Stress Regulators in Drug-Resistant Cancers
Although initial clinical responses to current standard chemotherapies are often dramatic, a significant number of cancer patients develop drug...
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Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research tool useful for investigating...
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RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis
ObjectiveEvidence suggests that calcium release from the endoplasmic reticulum (ER) can be induced to cause calcium overload, which in turn can...
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A Risk Signature Consisting of Eight m6A Methylation Regulators Predicts the Prognosis of Glioma
Glioma progression seriously correlates to the epigenetic context. This study aims to identify glioma subtypes by clustering analysis of patients...
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MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and chemotherapy are the...
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TGF-β-activated circRYK drives glioblastoma progression by increasing VLDLR mRNA expression and stability in a ceRNA- and RBP-dependent manner
BackgroundThe TGF-β signalling pathway is intricately associated with the progression of glioblastoma (GBM). The objective of this study was to...
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Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer
BackgroundWhile emerging evidence indicates that N 6 -methyladenosine (m 6 A) regulators play crucial roles in cancer progression, their clinical...
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E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities
BackgroundHuman malignancies are composed of heterogeneous subpopulations of cancer cells with phenotypic and functional diversity. Among them, a...
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ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells
BackgroundIntratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and...
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The Critical Role of RNA m6A Methylation in Gliomas: Targeting the Hallmarks of Cancer
Gliomas are the most common central cancer with high aggressive-capacity and poor prognosis, remaining to be the threat of most patients. With the...
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Off the Clock: the Non-canonical Roles of Cyclin-Dependent Kinases in Neural and Glioma Stem Cell Self-Renewal
Glioma stem cells (GSCs) are thought to drive growth and therapy resistance in glioblastoma (GBM) by “hijacking” at least a subset of signaling...
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Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape
Immunotherapy, especially immune checkpoint inhibitors (ICIs), has revolutionized the treatment of many types of cancer, particularly advanced-stage...
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Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Circadian disruption has become more prevalent in society due to the increase in shift work, sleep disruption, blue light exposure, and travel via...
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The multifaceted mechanisms of malignant glioblastoma progression and clinical implications
With the application of high throughput sequencing technologies at single-cell resolution, studies of the tumor microenvironment in glioblastoma, one...
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Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
BackgroundGlioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral...
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Sha** the brain vasculature in development and disease in the single-cell era
The CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis and disease. Angiogenesis —...
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Emerging role of m6A methylation modification in ovarian cancer
m6A (N6-methyladenosine) methylation, a well-known modification in tumour epigenetics, dynamically and reversibly fine tunes the entire process of...
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m6A modification: recent advances, anticancer targeted drug discovery and beyond
Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and...
