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Glutathione Peroxidase and Lung Cancer: An Unravel Story
Around 200 types of cancer are noted till date, among which lung cancer is the most commonly occurring cancer in men and the third most commonly...
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Antioxidant and Anti-Inflammatory Activity of 4-Hexylresorcinol
This chapter discusses the role of 4HR ointment in dental injury treatment and its potential to reduce oxidative stress and inflammation. Dental...
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Variants and Haplotypes of SIRT1 (rs7895833, rs7069102, and rs2273773) are Associated with the Risk of Preeclampsia and Affect the Trace Elements and Antioxidant Enzymes Levels
Preeclampsia is the most common and serious complication of pregnancy. Variants of Sirtuin-1 (SIRT1) as a key player in the regulation of...
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Effects of Sinapic Acid on Penicillin-Induced Epileptiform Activity in Rats
In our study, we investigated the effects of sinapic acid (SA), known for its antioxidant, antimicrobial, anti-inflammatory, and anticancer...
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Protective effects of diosmin on doxorubicin-induced testicular toxicity in rat
Doxorubicin (DOX) can be applied to treat several cancers. DOX-induced oxidative stress causes testicular damage. Diosmin (DIO), as a potent...
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Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats
Cisplatin, a chemotherapy drug containing platinum, is considered a neurotoxic agent. On the other hand, crocin, the primary component of saffron,...
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Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
Edaravone dexborneol (ED) is a novel neuroprotective compound that consists of two active ingredients, edaravone and ( +)-borneol in a 4:1 ratio,...
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Betaine alleviates doxorubicin-related cardiotoxicity via suppressing oxidative stress and inflammation via the NLRP3/SIRT1 pathway
Cardiotoxicity is one of the side effects of the anti-cancer drug doxorubicin (DOX) that limits its clinical application. Betaine (BT) is a natural...
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Tannic acid may ameliorate doxorubicin-induced changes in oxidative stress parameters in rat spleen
Doxorubicin (DOX) is a potent and broad-spectrum drug widely used in the treatment of cancer. However, the toxicity and side effects of DOX on...
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Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
AbstractParkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly related with oxidant status...
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In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts
Blueberries are rich in phenolic compounds including anthocyanins which are closely related to biological health functions. The purpose of this study...
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Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
Morphine (MPH) is widely used for pain management; however, long-term MPH therapy results in antinociceptive tolerance and physical dependence,...
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Prolactin is an Endogenous Antioxidant Factor in Astrocytes That Limits Oxidative Stress-Induced Astrocytic Cell Death via the STAT3/NRF2 Signaling Pathway
Oxidative stress-induced death of neurons and astrocytes contributes to the pathogenesis of numerous neurodegenerative diseases. While significant...
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Gemcitabine-loaded chitosan nanoparticles enhanced apoptotic and ferroptotic response of gemcitabine treatment alone in the pancreatic cancer cells in vitro
Gemcitabine (GEM) is a first-line treatment for pancreatic ductal adenocarcinoma (PDAC) patients, causing side effects and poor overall survival....
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Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice
Acetaminophen is widely used among humans as an antipyretic and analgesic. In this study, the protective effect of losartan in hepatotoxicity and...
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Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli (ETEC) K88-infected piglet
Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating properties. In this study, we built...
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D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
The aim of this research was to investigate the effects of d -limonene on decreasing post-operative adhesion in rats and to understand the mechanisms...
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Neuroprotective effects of dimethyl fumarate against manic-like behavior induced by ketamine in rats
Medications for treating bipolar disorder (BD) are limited and can cause side effects if used chronically. Therefore, efforts are being made to use...
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Cytokine profile and antioxidants status in the moderate and severe COVID-19 patients: a trial of ozone therapy impact as a medicinal supplement
BackgroundComplementary ozone therapy has been identified as a revolutionary medical technique for a number of goals and ailments. At the present, it...
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Andrographis paniculata Ameliorates Hyperammonemia Induced Oxidative Stress in Rat Brain by Activating Antioxidant Enzymes
AbstractLiver failure leads to hyperammonemia (HA), which trigger hepatic encephalopathy (HE), a neuropsychiatric syndrome. HA mediated oxidative...
