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Hereditary Cancer Syndromes and Cancer Metastasis
Hereditary cancer syndromes, also known as familial or inherited cancer syndromes, are inherited genetic disorders that are associated with increased...
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Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature
BackgroundIntracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of...
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Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy
Brain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the...
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Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters...
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Clinical and genomic correlates of imatinib response in melanomas with KIT alterations
BackgroundImatinib is an active agent for some patients with melanoma harbouring c-KIT alterations. However, the genetic and clinical features that...
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Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter
Metastasis to distant organs and particularly the brain still represents the most serious obstacle in melanoma therapies. Melanoma cells acquire a...
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Tyrosine kinase inhibitor–induced hypothyroidism: mechanism and clinical implications
IntroductionSince the first experimentally proven tyrosine kinase inhibitor (TKI) imatinib was introduced in the clinical setting, TKIs have...
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CSNK2 in cancer: pathophysiology and translational applications
Protein kinase CSNK2 (CK2) is a pleiotropic serine/threonine kinase frequently dysregulated in solid and hematologic malignancies. To consolidate a...
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Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes
Several medical conditions that interest both the brain and the spinal cordSpinal cord have been described throughout the history of medicine....
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Advances in Radioligand Theranostics in Oncology
Theranostics with radioligands (radiotheranostics) has played a pivotal role in oncology. Radiotheranostics explores the molecular targets expressed...
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Molecular targeted therapy for anticancer treatment
Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy...
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The Duchenne muscular dystrophy gene and cancer
BackgroundMutation of the Duchenne muscular dystrophy ( DMD) gene causes Duchenne and Becker muscular dystrophy, degenerative neuromuscular disorders...
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AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications
Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth...
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Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy
Gastrointestinal (GI) cancer is one of the lethal among all cancers which includes different types of cancers of the GI system, i.e., esophagus,...
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Small Molecular Immune Modulators as Anticancer Agents
After decades of intense effort, immune checkpoint inhibitors have been conclusively demonstrated to be effective in cancer treatments and thus are...
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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
l -Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal...
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Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary tumor in the central nervous system. One of the most widely used...
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Clinical development of targeted and immune based anti-cancer therapies
Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With...
