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HSV-1 latency-associated transcript miR-H3 and miR-H4 target STXBP1 and GABBR2 genes
During latent infection, the HSV-1 virus generates only a single transcript, LAT, which encodes six miRNAs. The GABAergic pathway signaling system is...
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A single nucleotide polymorphism-based formula to predict the risk of propofol TCI concentration being over 4 µg mL−1 at the time of loss of consciousness
We aim to develop a formula based on single nucleotide polymorphisms (SNPs) to predict whether the propofol target-controlled infusion (TCI)...
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Role of Neurotransmitter System Genes in Chronic Obstructive Pulmonary Disease
AbstractChronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease of the respiratory system. Smoking is a major risk...
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Effects of Chronic Social Stress on the Expression of Neurotransmitter System–Associated Genes in the Hypothalamus of Male Mice
AbstractChronic social stress caused by repeated negative experiences in agonistic interactions induces depressive-like behavior in male mice. The...
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Association of Polymorphisms in Neurotransmitter Genes and the TMEM18 Gene with Eating Behavior in Obese Patients
AbstractObesity and related complications are caused by eating disorders. The complex pathogenesis of the formation of food dependence has a genetic...
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GABAergic Neurotransmission Abnormalities in Pharmacoresistant Epilepsy: Experimental and Human Studies
Despite the fact that there are several drugs available for the treatment of epilepsy, pharmacoresistance remains a major challenge in seizure...
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Machine learning model for predicting Major Depressive Disorder using RNA-Seq data: optimization of classification approach
Considering human brain disorders, Major Depressive Disorder (MDD) is seen as a lethal disease in which a person goes to the extent of suicidal...
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Ocular and neural genes jointly regulate the visuospatial working memory in ADHD children
ObjectiveWorking memory (WM) deficits have frequently been linked to attention deficit hyperactivity disorder (ADHD). Despite previous studies...
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Eucommiae Folium and Active Compounds Protect Against Mitochondrial Dysfunction-Calcium Overload in Epileptic Hippocampal Neurons Through the Hypertrophic Cardiomyopathy Pathway
Epilepsy is a chronic brain disease and often occurs suddenly for no reason. Eucommiae folium (EF), an edible herb, can be used in the treatment of...
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Transcriptomic responses of bat cells to European bat lyssavirus 1 infection under conditions simulating euthermia and hibernation
BackgroundCoevolution between pathogens and their hosts decreases host morbidity and mortality. Bats host and can tolerate viruses which can be...
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Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy
Over 50 million people worldwide are affected by epilepsy, a common neurological disorder that has a high rate of drug resistance and diverse...
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Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning
BackgroundGenome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified several risk loci, but many remain unknown....
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Genetic Biomarkers of Psychiatric Disorders
Psychiatric disorders are multifactorial conditions known to have a significant genetic component, as seen in family, twin, and adoption studies....
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Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
Understanding the microglial neuro-immune interactions in the primate brain is vital to develo** therapeutics for cortical injury, such as stroke...
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Trait sensitivity to positive feedback is a predisposing factor for several aspects of compulsive alcohol drinking in male rats: behavioural, physiological, and molecular correlates
IntroductionAlcohol use disorder (AUD) is one of the most common psychiatric disorders and a leading cause of mortality worldwide. While the...
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GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway
BackgroundResearch has indicated that long-term sleep deprivation can lead to immune dysfunction and participate in the occurance and progression of...
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SynCAMs in Normal Vertebrate Neural Development and Neuropsychiatric Disorders: from the Perspective of the OCAs
Neuronal synaptic junctions connect neurons to enable neuronal signal transmission in the nervous system. The proper establishment of synaptic...
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Autism Spectrum Disorders and Ataxia
Autism is a neurodevelopmental disorder characterized by pervasive deficits in language, behavior, and cognition. Pathology exists throughout the...
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Gene selection by incorporating genetic networks into case-control association studies
Large-scale genome-wide association studies (GWAS) have been successfully applied to a wide range of genetic variants underlying complex diseases....
