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Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons
BackgroundMutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of...
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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germinal zone of the embryonic...
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U73122 and m-3M3FBS Regulate the GABAergic Neuron Regeneration via PLCβ in Planarian Dugesia japonica
AbstractThe planarian Dugesia japonica has a powerful regenerative capacity and can regenerate its whole body, including complete and functional...
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Electroacupuncture Alleviates Hyperalgesia and Anxiety-Like Behaviors in Pain Memory Model Rats Through Activation of GABAergic Neurons and GABA Receptor in the Rostral Anterior Cingulate Cortex
Recent studies have confirmed that pain memory is often accompanied by negative emotions. Electroacupuncture (EA) can block the retrieval of painful...
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α4 nicotinic receptors on GABAergic neurons mediate a cholinergic analgesic circuit in the substantia nigra pars reticulata
Nicotinic acetylcholine receptors (nAChRs) regulate pain pathways with various outcomes depending on receptor subtypes, neuron types, and locations....
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GABAergic Neurons in the Nucleus Accumbens are Involved in the General Anesthesia Effect of Propofol
The mechanism underlying the hypnosis effect of propofol is still not fully understood. In essence, the nucleus accumbens (NAc) is crucial for...
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Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic...
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Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model
BackgroundAlzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD...
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The Role of Slow Sodium Channels in GABAergic and NOergic Modulation of Nociceptive Neuron Excitability
Local voltage clam** and organotypic cultures of nervous tissue were used to study the actions of a series of agents whose activity is associated...
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The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections
Fluctuations in reproductive hormone levels are associated with mood disruptions in women, such as in postpartum and perimenopausal depression....
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GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter
GABAergic interneurons play a critical role in tuning neural networks in the central nervous system, and their defects are associated with...
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Activation of Cannabinoid Receptor 1 in GABAergic Neurons in the Rostral Anterior Insular Cortex Contributes to the Analgesia Following Common Peroneal Nerve Ligation
The rostral agranular insular cortex (RAIC) has been associated with pain modulation. Although the endogenous cannabinoid system (eCB) has been shown...
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Bi-directional Control of Synaptic Input Summation and Spike Generation by GABAergic Inputs at the Axon Initial Segment
Differing from other subtypes of inhibitory interneuron, chandelier or axo-axonic cells form depolarizing GABAergic synapses exclusively onto the...
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Shank3 Deficiency Results in a Reduction in GABAergic Postsynaptic Puncta in the Olfactory Brain Areas
Dysfunctional sensory systems, including altered olfactory function, have recently been reported in patients with autism spectrum disorder (ASD)....
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Synaptic Integration at Neuron-OPC Synapses
The synapses between neurons and oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS) have similar ultrastructures as...
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Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes
The mammalian brain contains multiple types of neuronal cells with complex assemblies and distinct structural and functional properties encoded by...
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Epidermal Growth Factor Suppresses the Development of GABAergic Neurons Via the Modulation of Perineuronal Net Formation in the Neocortex of Develo** Rodent Brains
Previously, we reported that epidermal growth factor (EGF) suppresses GABAergic neuronal development in the rodent cortex. Parvalbumin-positive...
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Neuron–oligodendroglial interactions in health and malignant disease
Experience sculpts brain structure and function. Activity-dependent modulation of the myelinated infrastructure of the nervous system has emerged as...
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Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome
AbstractThe SCN1A gene encodes the alpha subunit of a voltage-gated sodium channel (Na v 1.1), which is essential for the function of inhibitory...
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Function of the GABAergic System in Diabetic Encephalopathy
Diabetes is a common metabolic disease characterized by loss of blood sugar control and a high rate of complications. Îł-Aminobutyric acid (GABA)...
