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Transition Bias and Its Compensation in the Evolutionary Lineage of the Subfamily Murinae (Rodentia): Analysis of Nuclear and Mitochondrial DNA Markers
A comparative analysis of the rates of molecular evolution, transition bias, and its evolutionary compensation was carried out on mitochondrial...
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Taxonomic update for giant viruses in the order Imitervirales (phylum Nucleocytoviricota)
Large DNA viruses in the phylum Nucleocytoviricota , sometimes referred to as āgiant virusesā owing to their large genomes and virions, have been the...
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The Viruses Within ā How Human Are We?
The sequencing of the human genome revealed that 5ā8%of our DNA is not inherently human, but instead is viral DNA, primarily retroviral DNA. These...
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Expression levels of Fv1: effects on retroviral restriction specificities
BackgroundThe mouse protein Fv1 is a factor that can confer resistance to retroviral infection. The two major Fv1 alleles from laboratory mice, Fv1 ...
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Human Endogenous Retroviruses in Diseases
Human endogenous retroviruses (HERVs), which are conserved sequences of ancient retroviruses, are widely distributed in the human genome. Although...
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Revision to psychopharmacology mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex
ObjectivesThe prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and...
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A novel class III endogenous retrovirus with a class I envelope gene in African frogs with an intact genome and developmentally regulated transcripts in Xenopus tropicalis
BackgroundRetroviruses exist as exogenous infectious agents and as endogenous retroviruses (ERVs) integrated into host chromosomes. Such endogenous...
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Assessment of pulmonary function among cleaners in governmental hospitals in Addis Ababa, Ethiopia; comparative cross-sectional study
ObjectiveWork-related disorders are the major causes of different diseases in working populations. Respiratory disorders are among the most common...
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Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L
BackgroundAbout 10% of the mouse genome is composed of endogenous retroviruses (ERVs) that represent a molecular fossil record of past retroviral...
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Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARĪ³ Activation
The Angiotensin II Receptor Blocker (ARB) Telmisartan reduces inflammation through Angiotensin II AT1 receptor blockade and peroxisome...
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An efficient use of mixing model for computing the effective dielectric and thermal properties of the human head
As a preventive measure against the electromagnetic (EM) wave exposure to human body, EM radiation regulatory authorities such as ICNIRP and FCC...
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Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians
Inflammation was shown to be activated in varicose veins, although its role in the development of vein wall transformation remains inconclusive. We...
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Human-APOBEC3G-dependent restriction of porcine endogenous retrovirus replication is mediated by cytidine deamination and inhibition of DNA strand transfer during reverse transcription
Although human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G, hA3G)-mediated deamination is the major mechanism used...
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The Neuroprotective Role of the GM1 Oligosaccharide, II3Neu5Ac-Gg4, in Neuroblastoma Cells
Recently, we demonstrated that the GM1 oligosaccharide, II 3 Neu5Ac-Gg 4 (OligoGM1), administered to cultured murine Neuro2a neuroblastoma cells...
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PAS3-HSID: a Dynamic Bio-Inspired Approach for Real-Time Hot Spot Identification in Data Streams
Hot spot identification is a very relevant problem in a wide variety of areas such as health care, energy or transportation. A hot spot is defined as...
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Zika virus induces astrocyte differentiation in neural stem cells
Zika virus (ZIKV) is a rapidly emerging flavivirus that has been associated with a number of congenital neurological manifestations. Here, we show...
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The implications of the shared genetics of psychiatric disorders
Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders, including schizophrenia, bipolar disorder and major...
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Genetics of HIV-associated sensory neuropathy and related pain in Africans
Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological...
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Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction
BackgroundAPOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical...
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Toll-like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan
BackgroundLeishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. Despite several studies reporting involvement of...
