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Unveiling a novel fusion gene enhances CAR T cell therapy for solid tumors
The efficacy of Adoptive Cell Transfer Therapy (ACT) in combating hematological tumors has been well-documented, yet its application to solid tumors...
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A novel approach for direct detection of the IGH::CRLF2 gene fusion by fluorescent in situ hybridization
BackgroundHigh expression of the Cytokine Receptor-Like Factor 2 ( CRLF2 ) gene has been observed in patients with acute lymphoblastic leukemia...
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One novel ACOT7–NPHP4 fusion gene identified in one patient with acute lymphoblastic leukemia: a case report
BackgroundAcute lymphoblastic leukemia (ALL) is a type of heterogeneous hematopoietic malignancy that accounts for approximately 20% of adult ALL....
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Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway
BackgroundRearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a...
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Therapeutic Fusion Proteins
Therapeutic fusion proteins are a class of hybrid constructs that combine distinct biomolecules into a single platform with the additive effects of...
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Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing...
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The prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer
BackgroundIn breast cancer (BC), recurrent fusion genes of estrogen receptor alpha ( ESR1 ) and AKAP12 , ARMT1 and CCDC170 have been reported. In these...
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BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion
Methylation class “CNS tumor with BCOR/BCOR(L1)-fusion” was recently defined based on methylation profiling and tSNE analysis of a series of 21...
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A novel BRAF::PTPRN2 fusion in meningioma: a case report
Gene fusion events have been linked to oncogenesis in many cancers. However, gene fusions in meningioma are understudied compared to somatic...
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Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer
BackgroundTMPRSS2-ERG gene rearrangement, the most common E26 transformation specific (ETS) gene fusion within prostate cancer, is known to...
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Development and validation of sensitive BCR::ABL1 fusion gene quantitation using next-generation sequencing
BackgroundBCR::ABL1 fusion has significant prognostic value and is screened for chronic myeloid leukemia (CML) disease monitoring as a part of...
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Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show that ~5% of bladder cancer...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Protoplast Fusion for Cellular Engineering of the Brassicaceae
AbstractThe members of the Brassicaceae family are important oilseed, vegetable and forage crops. The Brassicaceae species are also used for...
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Ewing sarcoma treatment: a gene therapy approach
Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes...
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MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer
BackgroundThe long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) is a cancer biomarker. Furthermore, fusion of the MALAT1...
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Exploring the oncogenic and therapeutic target potential of the MYB-TYK2 fusion gene in B-cell acute lymphoblastic leukemia
TYK2- rearrangements have recently been identified in high-risk acute lymphoblastic leukemia (HR-ALL) cases and are associated with poor outcome....
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Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms
PurposeThis study examined the effects of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) on folliculogenesis and mitochondrial...
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Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion
Integration of molecular data with histologic, radiologic, and clinical features is imperative for accurate diagnosis of pediatric central nervous...
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The impact and outcomes of cancer-macrophage fusion
BackgroundCancer’s hallmark feature is its ability to evolve, leading to metastasis and recurrence. Although genetic mutations and epigenetic changes...
