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The full genome characterization of avian encephalomyelitis virus, Iran: a vertical transmission case
Avian encephalomyelitis (AE) is an important infectious poultry disease worldwide that is caused by avian encephalomyelitis virus (AEV). The...
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Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor
Adeno-associated virus (AAV) vector-based gene therapy is potentially curative for various genetic diseases; however, the development of a scalable...
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Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression
BackgroundNatural killer/T cell lymphoma (NKTCL) is a clinically and genetically heterogeneous disease with poor prognosis. Genome sequencing and...
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Near-full-length genome analysis of two novel HIV second recombinant forms in Hebei, China
The number of individuals infected with HIV-1 among men who have sex with men (MSM) has risen rapidly in recent years in China, and the subtypes...
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A full genome tiling array enhanced the inspection and quarantine of SARS-CoV-2
As the worldwide spreading epidemic of SARS-CoV-2, quick inspection and quarantine of passengers for SARS-CoV-2 infection are essential for...
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Full genome sequence of a novel iflavirus from the aster leafhopper Macrosteles fascifrons
The aster leafhopper Macrosteles fascifrons is a common insect pest that feeds on rice and other plants and may serve as a vector to transmit various...
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Application of full-genome analysis to diagnose rare monogenic disorders
Current genetic tests for rare diseases provide a diagnosis in only a modest proportion of cases. The Full-Genome Analysis method, FGA, combines...
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Full-genome characterisation of a putative novel serotype of Yonaguni orbivirus isolated from cattle in Yunnan province, China
In July 2019, a novel viral strain (JH2019C603) was isolated from sentinel cattle in **ghong City, in the subtropical region of Yunnan Province,...
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High molecular diversity of full-length genome sequences of zucchini yellow fleck virus from Europe
Zucchini yellow fleck virus (ZYFV), genus Potyvirus, is the causal agent of a disease of cucurbits. The genome sequences of seven ZYFV isolates of...
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Analytical characterization of full, intermediate, and empty AAV capsids
Manufacturing of recombinant adeno-associated virus (AAV) vectors produces three types of capsids: full, intermediate, and empty. While there are...
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Full-length genome characterization of a novel mitovirus isolated from the root rot fungus Armillaria mellea
Members of the genus Armillaria belong to the group of pathogenic and facultative saprotrophic fungi that are generally known as one of the causative...
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Full genome sequence of a novel iflavirus from the leafhopper Recilia dorsalis
The leafhopper Recilia dorsalis (family Cicadellidae, tribe Deltocephalini) is a common pest of rice and a transmitter of various viruses. Here, we...
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The full-length genome sequence of a novel amalgavirus in Lilium spp. in China
We report for the first time the complete genome sequence of a novel amalgavirus, tentatively designated as ‘lily amalgavirus 1’ (LAV-1), isolated...
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Complete genome sequence and construction of an infectious full-length cDNA clone of a cucumber vein yellowing virus (CVYV) isolate from Portugal
Cucumber vein yellowing virus (CVYV) is a member of the genus Ipomovirus in the family Potyviridae . In the National Center for Biotechnology...
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The Human Genome and Its Variations
In this chapter, we will briefly describe the genetic adaption of anatomically modern humans due to migration from Africa to new geographic and...
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Construction and characterization of a full-length infectious clone of an emerging senecavirus A strain
Senecavirus A (SVA) is an emerging virus that causes vesicular disease in pigs. Construction of a full-length SVA cDNA clone is crucial for...
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Genome Editing and Inherited Cardiac Arrhythmias
Inherited arrhythmic disorders are a group of heterogeneous diseases predisposing to life-threatening arrhythmias and sudden cardiac death. Their...
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Adeno-associated virus genome quantification with amplification-free CRISPR-Cas12a
Efficient manufacturing of recombinant Adeno-Associated Viral (rAAV) vectors to meet rising clinical demand remains a major hurdle. One of the most...
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CRISPR-Mediated Genome Engineering in Cell Lines
A specific targeting nuclease is a powerful tool for mediating genome alternative expression with high precision. The RNA sequence-guided Cas9...
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A graph-based genome and pan-genome variation of the model plant Setaria
Setaria italica (foxtail millet), a founder crop of East Asian agriculture, is a model plant for C4 photosynthesis and develo** approaches to...
