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Clinical spectrum of rare bone fragility disorders and response to bisphosphonate treatment: a retrospective study
Osteogenesis Imperfecta (OI) is a clinically and genetically heterogeneous group of diseases characterized by brittle bones. Though genetic mutations...
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Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However,...
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Microstructural fatigue fracture behavior of glycated cortical bone
AbstractThe current study aims to simulate fatigue microdamage accumulation in glycated cortical bone with increased advanced glycation end-products...
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A polygenic score associated with fracture risk in breast cancer patients treated with aromatase inhibitors
Identifying women at high risk of osteoporotic fracture from aromatase inhibitor (AI) therapy for breast cancer is largely based on known risk...
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Body Mass as a Biomarker and Femoral Fracture
Body mass represents a wide range of components, from atoms to tissues or organs. In clinical practice, body composition is generally assessed at the...
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Muscle strength is associated with fracture risk obtained by fracture risk assessment tool (FRAX) in women with breast cancer
BackgroundWomen with breast cancer are at risk for the development of sarcopenia and occurrence of fractures. The initial and periodic screening of...
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The Influence of Fall Direction and Hip Protector on Fracture Risk: FE Model Predictions Driven by Experimental Data
Hip fractures in older adults, which often lead to lasting impairments and an increased risk of mortality, are a major public health concern. Hip...
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Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Individual aged with various change in cell and cellular microenvironments and the skeletal system undergoes physiological changes that affect the...
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Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
BackgroundHip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hidden blood loss...
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Predictors of lower extremity fracture-related amputation in persons with traumatic spinal cord injury: a case–control study
Study designThis is a retrospective case–control study.
ObjectivesTo identify predictors of lower extremity (LE) long bone fracture-related...
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Body Mass as a Biomarker and Femoral Fracture
Body mass represents a wide range of components, from atoms to tissues or organs. In clinical practice, body composition is generally assessed at the...
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Low-intensity pulsed ultrasound partially reversed the deleterious effects of a severe spinal cord injury-induced bone loss and osteoporotic fracture healing in paraplegic rats
PurposeTo evaluate the effects of low-intensity pulsed ultrasound (LIPUS) on the quality of femoral fracture callus formation in rats with severe...
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Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk: An Update
Quantitative ultrasound (QUS) presents a low cost and readily available alternative to DXA measurements of bone mineral density (BMD) for...
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Prediction Criteria for the Formation of Refracture after Union of a Long Bone Fracture on the Basis of Hemodynamic Changes in the Tissues of the Area of Damage
We studied hemodynamic changes in the area of leg bone fracture and determined the prognostic criteria for refracture formation after achieved union....
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Personalised 3D Assessment of Trochanteric Soft Tissues Improves HIP Fracture Classification Accuracy
Passive soft tissues surrounding the trochanteric region attenuate fall impact forces and thereby control hip fracture risk. The degree of...
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Influence of non-osteoporotic treatments in patients on active anti-osteoporotic therapy: evidence from the OSTEOMED registry
PurposeTo evaluate the effect of different non-osteoporotic drugs on the increase or decrease in the risk of incident fragility fractures (vertebral,...
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Improving the Hip Fracture Risk Prediction with a Statistical Shape-and-Intensity Model of the Proximal Femur
Severe predictions have been made regarding osteoporotic fracture incidence for the next years, with major economic and social impacts in a...
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A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk
The current study evaluated the efficacy and safety of a denosumab biosimilar, QL1206 (60 mg), compared to placebo in postmenopausal Chinese women...
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Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
RationalePatients with schizophrenia with second-generation antipsychotics (SGAs) treatment have shown an increased risk of bone fragility and...
