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Footprint of Sound Emissions from Fishing Vessels in the Adriatic Sea
An underwater sound modeling assessment was performed of fishing boats in the Jabuka/Pomo Pit Fisheries Restricted Area (FRA) in the Adriatic Sea,...
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The expression analysis of Fra-1 gene and IL-11 protein in Iranian patients with ulcerative colitis
BackgroundFra-1 (fosl1) belongs to the activator protein1 (AP-1) family inducing IL-11 expression in oxidative stress condition. IL-11 plays a...
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Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion
BackgroundThe Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1...
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A Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily that was first identified as a factor favoring...
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Alternatively activated macrophages promote airway inflammation through JAK3–STAT5–Fra2 in asthma
BackgroundFos-related antigen-2 (Fra-2) is a transcription factor belonging to the activator protein 1 (AP-1) family, which is associated with many...
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
PurposeFor patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared with many solid tumors....
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Retrograde amnesia abolishes the self-reference effect in anterograde memory
Is retrograde amnesia associated with an ability to know who we are and imagine what we will be like in the future? To answer this question, we had...
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Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor
Activator protein-1 (AP-1) plays a decisive role in cell proliferation, apoptosis, and inflammation under hypoxia; thus, AP-1 subunits or dimers...
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SARS-CoV-2 Spike Protein S1 Exposure Increases Susceptibility to Angiotensin II-Induced Hypertension in Rats by Promoting Central Neuroinflammation and Oxidative Stress
The SARS-CoV-2 spike S1 subunit (S1) can cross the blood–brain barrier and elicit neuroinflammatory response independent of viral infection. Here we...
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Chromosome-level genomes of three key Allium crops and their trait evolution
Allium crop breeding remains severely hindered due to the lack of high-quality reference genomes. Here we report high-quality chromosome-level genome...
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Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex
BackgroundThe head-twitch response (HTR) in mice is considered a behavioral model for hallucinogens and serotonin 5-HT 2A receptor function, as well...
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FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat...
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Egocentric vision-based detection of surfaces: towards context-aware free-living digital biomarkers for gait and fall risk assessment
BackgroundFalls in older adults are a critical public health problem. As a means to assess fall risks, free-living digital biomarkers (FLDBs),...
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Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution
Clear cell renal cell carcinoma (ccRCC), as the most common histological subtype of kidney cancer, has been reported to originate primarily from...
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Influence of N-acetyltransferase 2 (NAT2) genotype/single nucleotide polymorphisms on clearance of isoniazid in tuberculosis patients: a systematic review of population pharmacokinetic models
PurposeSignificant pharmacokinetic variabilities have been reported for isoniazid across various populations. We aimed to summarize population...
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Prognostic and clinicopathological significance of transcription factor c-Jun in hypopharyngeal squamous cell carcinoma: a 3-year follow-up retrospective study
PurposeTo investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC).
MethodsA retrospective study...
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Molecular Markers Efficiency for Assessment of Genetic Structure in Barley Accessions
Abstract —Barley is the fourth most important grain crop in the world which is well-adapted to marginal and stress-prone environments, and hence a...
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High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation
BackgroundOesophageal cancer is one of the most common malignancies worldwide,and oesophageal squamous cell carcinoma (ESCC) is the predominant...
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Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs
Oncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. HPV genomes are integrated either...
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An ontogenic study of receptor mechanisms by which acute administration of low-doses of methamphetamine suppresses DOI-induced 5-HT2A-receptor mediated head-twitch response in mice
BackgroundMethamphetamine (MA) is a non-selective monoamine releaser and thus releases serotonin (5-HT), norepinephrine (NE) and dopamine (DA) from...
