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A novel variant in FOXC1 associated with atypical Axenfeld-Rieger syndrome
Mutations in the Forkhead Box C1 ( FOXC1 ) are known to cause autosomal dominant hereditary Axenfeld-Rieger syndrome, which is a genetic disorder...
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O-GlcNAcylation mediates H2O2-induced apoptosis through regulation of STAT3 and FOXO1
The O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is a critical post-translational modification that couples the external...
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Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with a high mortality rate and poor prognosis. Mutated or...
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Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple congenital abnormalities
PurposeHeterozygous pathogenic variants in various FOXP genes cause specific developmental disorders. The phenotype associated with heterozygous...
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Haploinsufficiencies of FOXF1, FOXC2 and FOXL1 genes originated from deleted 16q24.1q24.2 fragment related with alveolar capillary dysplasia with misalignment of pulmonary veins and lymphedema-distichiasis syndrome: relationship to phenotype
ObjectiveWe describe a fetus with a 2.12-Mb terminal deleted fragment in 16q associated with alveolar capillary dysplasia with misalignment of...
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FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat...
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Cardiac Progenitor Cells of the First and Second Heart Fields
The heart forms from the first and second heart fields, which contribute to distinct regions of the myocardium. This is supported by clonal analyses,...
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Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma
BackgroundCircular RNA (circRNA), an novel type of non-coding RNA, could interact with miRNA and protein molecules to regulate the occurrence and...
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A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
BackgroundMetastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial–mesenchymal...
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Prognostic Significance of FOXC1 in Various Cancers: A Systematic Review and Meta-Analysis
BackgroundForkhead box C1 (FOXC1), a member of the Forkhead box (Fox) transcription factor family, plays an essential role in lymphatic vessel...
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Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection
Cellular senescence, a hallmark of ageing, contributes to tissue or organ dysfunction and the pathophysiology of diverse age-related diseases (ARD)...
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Growth retardation and congenital heart disease in a boy with a ring chromosome 6 of maternal origin
BackgroundRare chromosomal structural abnormalities, including ring chromosomes, often pose challenges to clinical genetic counselling.
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Phenotype expansion of heterozygous FOXC1 pathogenic variants toward involvement of congenital anomalies of the kidneys and urinary tract (CAKUT)
PurposeCongenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in childhood and adolescence....
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FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
BackgroundForkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. FOX family protein lays a...
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Intellectual disability associated with craniofacial dysmorphism due to POLR3B mutation and defect in spliceosomal machinery
BackgroundIntellectual disability (ID) is a clinically important disease and a most prevalent neurodevelopmental disorder. The etiology and...
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The molecular subty** and precision medicine in triple-negative breast cancer---based on Fudan TNBC classification
Triple-negative breast cancer (TNBC) is widely recognized as the most aggressive form of breast cancer, occurring more frequently in younger patients...
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PI3K/Akt/mTOR-immunoreactive neurons in the rat mediobasal hypothalamus during aging
The hypothalamus is the regulatory hub controlling homeostasis, reproduction, circadian rhythms and endocrine system. It is also involved in the...
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Prenatal Diagnosis of Cerebellar Cortical Dysplasia: Case Report
This was a study of 12 cerebellar cortical dysplasias (CCDs) fetuses, these cases were characterized by a disorder of cerebellar fissures....
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Targeting SCF E3 Ligases for Cancer Therapies
SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for the degradation of proteins in a strictly regulated manner, through...
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Long Non-coding RNAs in Cancer
Long non-coding RNAs (lncRNAs) are emerging as cardinal biomarkers for diagnosis, prognosis, and therapy of cancers as well as precise therapeutic...