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Acute interstitial nephritis with podocyte foot-process effacement complicating Plasmodium falciparum infection
BackgroundMalarial acute renal failure (MARF) is a component of the severe malaria syndrome, and complicates 1–5% of malaria infections. This form of...
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Detrimental effects of hypoxia on glomerular podocytes
Hypoxia-inducible factor1 (HIF1) plays a pivotal role in ensuring cells adapt to low-oxygen conditions. Depletion of oxygen, a co-substrate during...
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Engulfment and Cell Motility Protein (ELMO)-1 as a Biomarker in Type II Diabetes
Increasing prevalence of T2DM in parallel with increased prevalence of DN, which leading cause of ESRD and T2DM. Albuminuria as a standard biomarker...
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IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease
Podocyte apoptosis or loss is the pivotal pathological characteristic of diabetic kidney disease (DKD). Insulin-like growth factor-binding protein 2...
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Histone modification in podocyte injury of diabetic nephropathy
Diabetic nephropathy (DN), an important complication of diabetic microvascular disease, is one of the leading causes of end-stage renal disease...
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Engulfment and Cell Motility Protein (ELMO)-1 as a Biomarker in Type II Diabetes
Increasing prevalence of T2DM in parallel with increased prevalence of DN, which leading cause of ESRD and T2DM. Albuminuria as a standard biomarker...
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Capillary rarefaction: a missing link in renal and cardiovascular disease?
Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality. Capillary rarefaction may be both one...
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Blockade of Notch1 Signaling Alleviated Podocyte Injury in Lupus Nephritis Via Inhibition of NLRP3 Inflammasome Activation
To explore the role of Notch1 pathway in the pathogenesis of podocyte injury, and to provide novel strategy for podocyte repair in lupus nephritis...
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The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease
The Shroom (Shrm) family of actin-binding proteins has a unique and highly conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the...
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Regulation of NLRP3 Inflammasome Activation and Inflammatory Exosome Release in Podocytes by Acid Sphingomyelinase During Obesity
The activation of nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome has been reported to...
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Novel Pathogenic Mutation of P209L in TRPC6 Gene Causes Adult Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a leading kidney disease, clinically associated with proteinuria and progressive renal failure. The...
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Novel pathogenic variants in CUBN uncouple proteinuria from renal function
BackgroundProteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney...
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Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway
Sirtuins (Sirts) are a family of nicotinamide adenine dinucleotide-dependent protein deacetylases that share diverse cellular functions. Increasing...
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Immune-mediated entities of (primary) focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy...
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A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane
AbstractNot only in kidney glomerular physiological function but also glomerular pathology especially in diabetic condition, glomerular podocytes...
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Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis
BackgroundFocal and segmental glomerulosclerosis (FSGS) is a histological pathology that characterizes a wide spectrum of diseases. Many genes...
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The glomerular filtration barrier: a structural target for novel kidney therapies
Loss of normal kidney function affects more than 10% of the population and contributes to morbidity and mortality. Kidney diseases are currently...
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Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity
Panax notoginseng , a traditional Chinese medicine, exerts beneficial effect on diabetic kidney disease (DKD), but its mechanism is not well...
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Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury
BackgroundIt is widely acknowledged that cisplatin-induced nephrotoxicity hinders its efficacy during clinical therapy. Effective pharmaceutical...
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Axon guidance molecules in immunometabolic diseases
The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic...
