Search
Search Results
-
Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
Patients with Alzheimer's disease have increased risk of develo** heart disease, which therefore highlights the need for strategies aiming at...
-
Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment
Insufficient dietary folate intake, hereditary malabsorption, or defects in folate transport may lead to combined immunodeficiency (CID). Although...
-
Nanoliposomal irinotecan plus fluorouracil and folinic acid as a second-line treatment option in patients with metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study
BackgroundAccording to the NAPOLI-1 trial, nanoliposomal irinotecan (nal-IRI) plus fluorouracil/folinic acid (5-FU/LV) showed improved overall...
-
Study protocol of an open-label, single arm phase II trial investigating the efficacy, safety and quality of life of neoadjuvant chemotherapy with liposomal irinotecan combined with Oxaliplatin and 5-fluorouracil/Folinic acid followed by curative surgical resection in patients with hepatic Oligometastatic adenocarcinoma of the pancreas (HOLIPANC)
BackgroundAccording to current guidelines, treatment of patients with hepatic oligometastasis in pancreatic cancer is not reflected and systemic...
-
Homocysteine and Folic Acid Metabolism
Homocysteine (Hcy) and folate metabolism plays a crucial role in maintaining the overall human health. Hcy is a non-proteinogenic amino acid...
-
Pharmacotherapy of Vitamin B12 and Folic Acid Deficiency
In Southeast Asia, Mexico, and selected parts of Africa and America, nutritional deficiency of vitamin B12 and folic acid is the commonest cause of...
-
Thyroid hormone and folinic acid in young children with Down syndrome: the phase 3 ACTHYF trial
PurposeTo determine whether folinic acid (FA) and thyroxine, in combination or alone, benefit psychomotor development in young patients with Down...
-
Single-organ pulmonary metastasis is a favorable prognostic factor in metastatic colorectal cancer patients treated with FOLFIRI and vascular endothelial growth factor inhibitors
BackgroundFew studies have focused on the impact of single-organ pulmonary metastases on progression-free survival and overall survival in patients...
-
Cerebral folate transporter deficiency: a potentially treatable neurometabolic disorder
Cerebral folate deficiency (CFD) syndrome is a rare treatable neurometabolic disorder with low levels of the active form of folaten in cerebrospinal...
-
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy....
-
CRISPR/Cas9-mediated silencing of CD44: unveiling the role of hyaluronic acid-mediated interactions in cancer drug resistance
A comprehensive overview of CD44 (CD44 Molecule (Indian Blood Group)), a cell surface glycoprotein, and its interaction with hyaluronic acid (HA) in...
-
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by develo** evidence-based pharmacogenetics guidelines to...
-
Disorders of Tetrahydrobiopterin Metabolism: Experience from South India
BackgroundDisorders of tetrahydrobiopterin metabolism represent a rare group of inherited neurotransmitter disorders that manifests mainly in infancy...
-
Hepatic arterial infusion in combination with systemic chemotherapy in patients with hepatic metastasis from colorectal cancer: a randomized phase II study – (NCT05103020) – study protocol
BackgroundAlthough 80% of patients with metastatic colorectal cancer (CRC) experience liver metastases, only 10–25% undergo resection at the time of...
-
Comparison the efficacy and safety of different neoadjuvant regimens for resectable and borderline resectable pancreatic cancer: a systematic review and network meta-analysis
BackgroundTo date, the optimal recommended specific neoadjuvant regimens for resectable or borderline resectable pancreatic cancer (RPC or BRPC)...
-
Treatment sequences and prognostic/predictive factors in metastatic pancreatic ductal adenocarcinoma: univariate and multivariate analyses of a real-world study in Europe
BackgroundReal-world data on treatment patterns/outcomes for metastatic pancreatic cancer (mPAC) are limited. This study aims to assess real-world...
-
FOLFIRINOX-R study design: a phase I/II trial of FOLFIRINOX plus regorafenib as first line therapy in patients with unresectable RAS-mutated metastatic colorectal cancer
BackgroundThe chemotherapy triplet FOLFOXIRI combined to the anti-VEGF antibody bevacizumab is an option in selected patients with metastatic...
-
Pharmacogenetics in Epilepsy and Refractory Epilepsy
Pharmacogenomic studies in epilepsy are necessary due to the high prevalence of this disease and the high percentage of drug resistance phenotype....
-
Cost-effectiveness of ivosidenib versus chemotherapy for previously treated IDH1-mutant advanced intrahepatic cholangiocarcinoma in Taiwan
BackgroundInternational guidelines recommend ivosidenib followed by modified FOLFOX (mFOLFOX) for advanced intrahepatic cholangiocarcinoma (ICC) with...
-
The genetic and clinical characteristics of aromatic L-amino acid decarboxylase deficiency in mainland China
Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare neurotransmitter metabolic disorder caused by DDC gene mutations, which leads to the...
