Search
Search Results
-
Idiopathic intracranial hypertension secondary to fluoroquinolone therapy: French pharmacovigilance data review
We investigate spontaneous reports of IIH related to fluoroquinolones recorded in the French national pharmacovigilance database in order to detect a...
-
Comparison of gradient diffusion and molecular methods using Allplex™ NG&DR assay (Seegene®) for macrolide and fluoroquinolone screening resistance in Neisseria gonorrhoeae
Antimicrobial resistance in Neisseria gonorrhoeae (NG) is increasing worldwide. Second-line treatments with macrolides or fluoroquinolones are an...
-
A New Fluoroquinolone: Delafloxacin
The fluoroquinolones have been in clinical use for over 50 years for community- and hospital-associated infections, but widespread, often...
-
Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice
Infection with Mycobacterium tuberculosis ( Mtb ) results in the primary formation of a densely packed inflammatory foci that limits entry of...
-
The molecular mechanisms of fluoroquinolone resistance found in rectal swab isolates of Enterobacterales from men undergoing a transrectal prostate biopsy: the rationale for targeted prophylaxis
BackgroundTransrectal ultrasound-guided prostate biopsy (TRUS-Bx) is considered an essential urological procedure for the histological diagnosis of...
-
Synthesis, antibacterial evaluation and in silico study of DOTA-fluoroquinolone derivatives
A series of water-soluble fluoroquinolones based upon DOTA (1,4,7,10-tetraazacyclododecane -1,4,7,10-tetraacetic acid) modification were synthesized...
-
Evaluating outcomes associated with revised fluoroquinolone breakpoints for Enterobacterales urinary tract infections: A retrospective cohort study
PurposeIn 2019, minimum inhibitory concentration (MIC) breakpoints of ciprofloxacin and levofloxacin for Enterobacterales were lowered. This study...
-
Modeling the risk of fluoroquinolone resistance in non-severe community-onset pyelonephritis
Estimating whether the individual probability of being infected by a fluoroquinolone resistant isolate is higher than 10% may help to choose the...
-
Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru
ObjectiveTo determine at two distinct time points the prevalence of resistance to ofloxacin (OFX), the representative class drug of fluoroquinolones...
-
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region
BackgroundMultidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains are a serious health problem in India, also contributing to...
-
Efficacy and Therapeutic Drug Monitoring of Continuous Beta-Lactam Infusion for Osteoarticular Infections Caused by Fluoroquinolone-Resistant Pseudomonas aeruginosa: A Prospective Cohort Study
Background and ObjectivesOsteoarticular infections (OIs) caused by fluoroquinolone-resistant Pseudomonas aeruginosa , including multidrug-resistant...
-
Fluoroquinolone resistance of Staphylococcus epidermidis isolated from healthy conjunctiva and analysis of their mutations in quinolone-resistance determining region
BackgroundStaphylococcus epidermidis is the most common pathogen in postoperative endophthalmitis and causes various infectious eye diseases....
-
Re-evaluating the suitability of using fluoroquinolones in the treatment of infections in the context of FQ consumption and correlating changes to microorganism resistance levels in EU/EEA countries between 2016 and 2021
The aim of this study was to re-evaluate fluoroquinolone (FQ) use in treatment by analyzing the consumption of FQ and the resistance levels of...
-
Usefulness of dynamic regression time series models for studying the relationship between antimicrobial consumption and bacterial antimicrobial resistance in hospitals: a systematic review
BackgroungAntimicrobial resistance (AMR) is on the rise worldwide. Tools such as dynamic regression (DR) models can correlate antimicrobial...
-
The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens
Coccidiosis is a crucial parasitic disease of the poultry industry. As a result of the enormous global economic losses and the increased resistance...
-
Synthesis and antimycobacterial evaluation of fluoroquinolones derivatives coupled with isoprenyl moiety at the C-7 position
In this work, we report the synthesis and antitubercular activity of sixteen fluoroquinolones analogs of Cipro-, Gati-, Moxi-, and Gemifloxacin...
-
Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization
Microbiota promotes or inhibits the pathogenesis of a range of immune-mediated disorders. Although recent studies have elucidated the role of gut...
-
Appraisal of fluoroquinolone-loaded carubinose-linked hybrid nanoparticles for glycotargeting to alveolar macrophages
There is a curious case in Alveolar macrophages (AM), the frontline defence recruits that contain the spread of all intruding bacteria. In response...
-
Co-localization of antibiotic resistance genes is widespread in the infant gut microbiome and associates with an immature gut microbial composition
BackgroundIn environmental bacteria, the selective advantage of antibiotic resistance genes (ARGs) can be increased through co-localization with...
-
Efficient Turn-On Zr Based Metal Organic Framework Fluorescent Sensor for Ultrafast Detection of Danofloxacin in Milk Samples
Metal organic framework, UiO-67 was synthesized by coordinating Zr(IV) with 4,4’-biphenyldicarboxylic acid (BPDC) ligand. Morphology and...
