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Brain imaging of a gamified cognitive flexibility task in young and older adults
The study aimed to develop and validate a gamified cognitive flexibility task through brain imaging, and to investigate behavioral and brain...
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Premorbid performances determine the deleterious effects of nigrostriatal degeneration and pramipexole on behavioural flexibility
Subtle cognitive impairment can occur early in the course of Parkinson’s disease (PD) and may manifest under different forms of executive dysfunction...
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5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence
RationaleCognitive flexibility, the ability to adapt behaviour in response to a changing environment, is disrupted in several neuropsychiatric...
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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic flexibility...
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Acute effect of static stretching on non-muscular tissue stiffness and joint flexibility: a comparative study between older and young men
PurposeNon-muscular tissue stiffness is assumed to have a negative impact on joint flexibility, and a reduction in non-muscular tissue stiffness may...
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Enhanced brain network flexibility by physical exercise in female methamphetamine users
Methamphetamine (MA) abuse is increasing worldwide, and evidence indicates that MA causes degraded cognitive functions such as executive function,...
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Ketamine produces no detectable long-term positive or negative effects on cognitive flexibility or reinforcement learning of male rats
RationalePatients with major depressive disorder (MDD) often experience abnormalities in behavioral adaptation following environmental changes (i.e.,...
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Comparison of the effects of long-lasting static stretching and hypertrophy training on maximal strength, muscle thickness and flexibility in the plantar flexors
Maximal strength measured via maximal voluntary contraction is known as a key factor in competitive sports performance as well as injury risk...
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Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations
BackgroundMajor histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic...
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Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility
Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical...
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The Delay Discounting Procedure: Methodology and Flexibility
Delay discounting (DD) is a well-established method for evaluating behavioral impulsivity. It has been implemented extensively over the past few...
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L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task
RationaleThe cognitive control dilemma describes the necessity to balance two antagonistic modes of attention: stability and flexibility. Stability...
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Beyond assembly: the increasing flexibility of single-molecule sequencing technology
The maturation of high-throughput short-read sequencing technology over the past two decades has shaped the way genomes are studied. Recently,...
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Interaction of cholinergic disruption and age on cognitive flexibility in rats
Healthy aging is associated with a functional reduction of the basal forebrain (BF) system that supplies the neurochemical acetylcholine (ACh) to the...
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Cognitive and behavioural flexibility: neural mechanisms and clinical considerations
Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and behaviours in response to changing environmental demands....
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Effects of chronic tramadol administration on cognitive flexibility in mice
RationaleTramadol is widely used for pain relief especially in seniors. However, long-term use of tramadol has serious adverse effects, including...
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Neural correlates of schema-dependent episodic memory and association with behavioral flexibility in autism spectrum disorders and typical development
BackgroundConceptual knowledge frameworks termed schemas facilitate memory formation and are posited to support flexible behavior. In adults, the...
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Dissociable plasticity of visual-motor system in functional specialization and flexibility in expert table tennis players
Specialization and flexibility are two basic attributes of functional brain organization, enabling efficient cognition and behavior. However, it is...
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CNG channel structure, function, and gating: a tale of conformational flexibility
Cyclic nucleotide–gated (CNG) channels are key to the signal transduction machinery of certain sensory modalities both in vertebrate and invertebrate...
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MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice
MicroRNAs are known to be critical regulators of neuronal plasticity. The highly conserved, hypoxia-regulated microRNA-210 (miR-210) has been shown...
