Search
Search Results
-
Aspalathin, a Primary Rooibos Flavonoid, Alleviates Mast Cell-Mediated Allergic Inflammation by the Inhibition of FcεRI Signaling Pathway
Mast cells are primary cells initiating allergic inflammation by the release of various allergic mediators, such as histamine and pro-inflammatory...
-
Flavonoid-Based Derivatives for Modulating Various Targets of Alzheimer’s Disease
Alzheimer’s disease (AD), an advanced multifactorial neurodegenerative disease mainly accompanied by cognitive impairment, is the most conversant...
-
Natural Flavonoid Apigenin, an Effective Agent Against Nervous System Cancers
Cancer is a serious public health concern worldwide, and nervous system (NS) cancers are among the most life-threatening malignancies. Efforts have...
-
Association of dietary flavonoid intakes with prevalence of chronic respiratory diseases in adults
Background and aimsFlavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant...
-
Kaempferol-3-O-Rutinoside: A Natural Flavonoid Glycosides with Multifaceted Therapeutic Potential
AbstractKaempferol-3- O -rutinoside is a flavonoid glycoside extracted from traditional Chinese medicine, plants and tea. The provide evidence has...
-
Kurarinone, a flavonoid from Radix Sophorae Flavescentis, inhibits RANKL-induced osteoclastogenesis in mouse bone marrow–derived monocyte/macrophages
Inflammation-induced osteoclast proliferation is a crucial contributor to impaired bone metabolism. Kurarinone (KR), a flavonoid extracted from the Rad...
-
Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin
BackgroundDNA ligases are crucial for DNA repair and cell replication since they catalyze the final steps in which DNA breaks are joined. DNA Ligase...
-
A mechanistic review of the pharmacological potential of narirutin: a dietary flavonoid
Flavanones, a type of polyphenol, are found in substantial amounts in citrus fruits. When high- or moderate-dose orange juice consumption occurs,...
-
Adaptive Significance and Origin of Flavonoid Biosynthesis Genes in the Grain of Cultivated Cereals
AbstractThe majority of cultivated cereals including maize, rice, wheat, barley, oat and rye consist of numerous varieties lacking anthocyanin...
-
Acacetin Attenuates Sepsis-induced Acute Lung Injury via NLRC3-NF-κB Pathway
Acacetin, a flavonoid derived compound has been recognized for its diverse biological activities, such as anti-oxidative and anti-inflammatory...
-
Defense Against Oxidative Stress: Nrf2-ARE Pathway
Reactive chemical intermediates, including reactive oxygen and nitrogen species and free radicals, are formed during foreign compound metabolic...
-
Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids
Neuroinflammatory responses to neurotoxic manganese (Mn) in CNS have been associated with the Mn-induced Parkinson-like syndromes. However, the...
-
Luteolin: a flavonoid with a multifaceted anticancer potential
Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as...
-
Quercetin: A Promising Flavonoid for the Therapy of Cardiac Hypertrophy and Heart Failure Mediated by the Renin Angiotensin System
The Renin angiotensin systemRenin angiotensin system (RAS) plays an essential role in regulating the angiotensin IIAngiotensin II levels in the body...
-
Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity
Causes of dopaminergic neuronal loss in Parkinson’s disease (PD) are subject of investigation and the common use of models of acute neurodegeneration...
-
Malvidin alleviates LPS-induced septic intestinal injury through the nuclear factor erythroid 2-related factor 2/reactive oxygen species/NLRP3 inflammasome pathway
Emerging evidence suggests that the gastrointestinal tract plays a crucial role in the pathophysiology of sepsis, a leading cause of mortality among...
-
Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway
Licochalcone A (Lico A), a flavonoid found in licorice, possesses multiple pharmacological activities in modulating oxidative stress, glycemia,...
-
The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
The prominence of autophagy in the modulation of neurodegenerative disorders has sparked interest to investigate its stimulation in Alzheimer's...
-
Quercetin attenuates Pseudomonas aeruginosa-induced acute lung inflammation by inhibiting PI3K/AKT/NF-κB signaling pathway
Pseudomonas aeruginosa is an opportunistic pathogen that commonly causes infections in immunocompromised individuals with significant morbidity and...
-
Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway
Microglial activation underpins the methotrexate (MTX)-induced neurotoxicity; however, the precise mechanism remains unclear. This study appraised...
