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Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation
Fibrotic scars play important roles in tissue reconstruction and functional recovery in the late stage of nervous system injury. However, the...
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Hematogenous Macrophages Contribute to Fibrotic Scar Formation After Optic Nerve Crush
Although glial scar formation has been extensively studied after optic nerve injury, the existence and characteristics of traumatic optic nerve...
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Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury
Astroglial-fibrotic scars resulted from spinal cord injury affect motor and sensory function, leading to paralysis. In particular, the fibrotic scar...
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Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis
BackgroundHypertrophic scar is a fibrotic disease following wound healing and is characterized by excessive extracellular matrix deposition....
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SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway
BackgroundExcessively deposited fibrotic scar after spinal cord injury (SCI) inhibits axon regeneration. It has been reported that platelet-derived...
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Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue
Despite the substantial impact of skin scarring on patients and the healthcare system, there is a lack of strategies to prevent scar formation, let...
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Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14–3-3ζ
Cerebral ischemic stroke is one of the leading causes of human death. The fibrous scar is one of major factors influencing repair in central nervous...
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CNS fibroblasts form a fibrotic scar in response to immune cell infiltration
Fibrosis is a common pathological response to inflammation in many peripheral tissues and can prevent tissue regeneration and repair. Here, we...
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Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases
MicroRNAs (miRNAs) are endogenous noncoding RNAs that mediate the fibrotic process by regulating multiple targets. MicroRNA-based therapy can restore...
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Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration
After traumatic injury, healing of mammalian ligaments is typically associated with fibrotic scarring as opposed to scar-free regeneration. In...
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New progress of tuberculosis scar carcinoma
It has been demonstrated that scar tissue and fibrosis may increase the likelihood of develo** malignancies. Specifically, scar tissue has been...
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Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature
Fibrosis is a process of pathological tissue repair that replaces damaged, formerly functional tissue with a non-functional, collagen-rich scar....
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Temporal dynamics of cells expressing NG2 and platelet-derived growth factor receptor-β in the fibrotic scar formation after 3-nitropropionic acid-induced acute brain injury
Neuron-glia antigen 2 (NG2) proteoglycan and platelet-derived growth factor receptor beta (PDGFR-β) are widely used markers of pericytes, which are...
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Valproic acid modulates collagen architecture in the postoperative conjunctival scar
AbstractValproic acid (VPA), widely used for the treatment of neurological disorders, has anti-fibrotic activity by reducing collagen production in...
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Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which play a crucial role in injury repair. Fibrosis attributes...
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Multi-modal assessment of a cardiac stem cell therapy reveals distinct modulation of regional scar properties
BackgroundThe initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by...
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Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts
BackgroundAbnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current...
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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin...
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Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors – the glial...
