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Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a long-known complex neurodevelopmental disorder, and over the past decades, with the enhancement of the research...
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Urothelial Bladder Cancer: Genomic Alterations in Fibroblast Growth Factor Receptor
Background and ObjectiveGenomic alterations in fibroblast growth factor receptor ( FGFR) genes have been linked to a reduced response to immune...
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The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer
PurposeThe gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeutic options remain...
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Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Objective and designCompelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel...
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Fibroblast growth factor receptor type 4 as a potential therapeutic target in clear cell renal cell carcinoma
BackgroundSeveral clear cell renal cell carcinoma (ccRCC) cases harbour fibroblast growth factor receptor 4 ( FGFR4 ) gene copy number (CN) gains. In...
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Fibroblast growth factor-21 alleviates proteasome injury via activation of autophagy flux in Parkinson’s disease
Parkinson’s disease (PD) is one of the most common and complex Neurodegeneration, with an inherited metabolic disorder. Fibroblast growth factor 21...
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Fibroblast growth factor 21 (FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB (TFEB)-regulated lipophagy
Tacrolimus (TAC), also called FK506, is one of the classical immunosuppressants to prevent allograft rejection after liver transplantation. However,...
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The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM)
Fibroblast growth factor 21 (FGF21) is a peptide hormone mainly synthesized and released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and...
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Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors
We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP, ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular...
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Fibroblast Growth Factor 2 Levels in Patients with Major Depressive Disorder: A Meta-analysis
Fibroblast growth factor 2 (FGF2) plays an essential role in neurogenesis, oxidative stress, and emotional behavior. However, the evidence regarding...
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Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness
Glioblastoma (GBM) is characterized by a particularly invasive phenotype, supported by oncogenic signals from the fibroblast growth factor (FGF)/ FGF...
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Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
Fibroblast growth factor 21 (FGF21) is expressed in several organs, including the liver, adipose tissue, and cardiovascular system, and plays an...
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Fibroblast growth factor receptor fusions in cancer: opportunities and challenges
Fibroblast growth factors (FGFs) and their receptors (FGFRs) play critical roles in many biological processes and developmental functions....
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Fibroblast growth factor 2 reduces endoplasmic reticulum stress and apoptosis in in-vitro Non-Alcoholic Fatty Liver Disease model
PurposeNon-Alcoholic fatty liver disease is characterized by the accumulation of excess fat in the liver, chronic inflammation, and cell death,...
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Fibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening disease without an effective drug at present. Fibroblast...
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Fibroblast Growth Factor 23 as Regulator of Vitamin D Metabolism
Fibroblast growth factor 23 (FGF23FGF23) is a hormone produced by osteocytesOsteocytes in bone that acts on the kidneys to regulate phosphate and...
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Basic Fibroblast Growth Factor Opens and Closes the Endothelial Blood–Brain Barrier in a Concentration-Dependent Manner
Multiple paracrine factors are implicated in the regulation of barrier properties of human brain endothelial cells (BECs) in different physiologic...
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P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
This study was designed to investigate the potential of extracellular adenosine 5′-triphosphate (ATP) via the P2 X 7 receptor to activate the renal...
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Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer
BackgroundOvarian cancer patients frequently develop chemotherapy resistance, limiting treatment options. We have previously shown that individuality...
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A multicenter investigator-initiated Phase 2 trial of E7090 in patients with advanced or recurrent solid tumor with fibroblast growth factor receptor (FGFR) gene alteration: FORTUNE trial
BackgroundAberrant fibroblast growth factor receptor (FGFR) signaling can substantially influence oncogenicity. Despite that FGFR gene abnormality is...
